Predicting Permissive Mutations That Improve the Fitness of A(H1N1)pdm09 Viruses Bearing the H275Y Neuraminidase Substitution

Oseltamivir-resistant influenza viruses arise due to amino acid mutations in key residues of the viral neuraminidase (NA). These changes often come at a fitness cost; however, it is known that permissive mutations in the viral NA can overcome this cost. This result was observed in former seasonal A(...

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Detalles Bibliográficos
Autores principales: Farrukee, Rubaiyea, Gunalan, Vithiagaran, Maurer-Stroh, Sebastian, Reading, Patrick C., Hurt, Aeron C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Genetic Diversity and Evolution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364793/
https://www.ncbi.nlm.nih.gov/pubmed/35867563
http://dx.doi.org/10.1128/jvi.00918-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364793/
https://www.ncbi.nlm.nih.gov/pubmed/35867563
http://dx.doi.org/10.1128/jvi.00918-22

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