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Pretransplantation seroreactivity in kidney donors and recipients as a predictive factor for posttransplant BKPyV-DNAemia

BK polyomavirus (BKPyV) often reactivates after kidney transplantation, causing BKPyV-associated nephropathy (BKPyVAN) in 1%–10% of cases with a potential detrimental effect on allograft survival. Kidney transplant recipients are regularly screened for BKPyV DNA in plasma. As this strategy may not a...

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Autores principales: Saláková, Martina, Ludvíková, Viera, Hamšíková, Eva, Kolářová, Marie, Šroller, Vojtěch, Viklický, Ondřej, Wohlfahrtová, Mariana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364833/
https://www.ncbi.nlm.nih.gov/pubmed/35967393
http://dx.doi.org/10.3389/fimmu.2022.929946
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author Saláková, Martina
Ludvíková, Viera
Hamšíková, Eva
Kolářová, Marie
Šroller, Vojtěch
Viklický, Ondřej
Wohlfahrtová, Mariana
author_facet Saláková, Martina
Ludvíková, Viera
Hamšíková, Eva
Kolářová, Marie
Šroller, Vojtěch
Viklický, Ondřej
Wohlfahrtová, Mariana
author_sort Saláková, Martina
collection PubMed
description BK polyomavirus (BKPyV) often reactivates after kidney transplantation, causing BKPyV-associated nephropathy (BKPyVAN) in 1%–10% of cases with a potential detrimental effect on allograft survival. Kidney transplant recipients are regularly screened for BKPyV DNA in plasma. As this strategy may not always reduce the risk of BKPyVAN, other predictive markers are needed. To evaluate the role of pretransplant BKPyV-specific antibody, 210 kidney transplant recipients and 130 donors were screened for BKPyV DNA and BKPyV-specific antibodies. We found that the donor BKPyV immunoglobulin G (IgG) seroprevalence and antibody level were strongly associated with BKPyV-DNAemia and BKPyVAN, although multivariant analysis found the presence of anti-BKPyV-specific antibodies as a predictive factor only for BKPyV-DNAemia. The pretransplant recipient status had no effect on posttransplant BKPyV-DNAemia and BKVAN. BKPyV IgG levels remained stable in BKPyV-negative recipients during 1-year follow-up, while a considerable increase was observed in BKPyV-positive patients. The presence of anti-BKPyV-specific antibodies in kidney allograft donors is a good and reliable predictive marker for posttransplant BKPyV replication with relevance to risk stratification in transplant recipients.
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spelling pubmed-93648332022-08-11 Pretransplantation seroreactivity in kidney donors and recipients as a predictive factor for posttransplant BKPyV-DNAemia Saláková, Martina Ludvíková, Viera Hamšíková, Eva Kolářová, Marie Šroller, Vojtěch Viklický, Ondřej Wohlfahrtová, Mariana Front Immunol Immunology BK polyomavirus (BKPyV) often reactivates after kidney transplantation, causing BKPyV-associated nephropathy (BKPyVAN) in 1%–10% of cases with a potential detrimental effect on allograft survival. Kidney transplant recipients are regularly screened for BKPyV DNA in plasma. As this strategy may not always reduce the risk of BKPyVAN, other predictive markers are needed. To evaluate the role of pretransplant BKPyV-specific antibody, 210 kidney transplant recipients and 130 donors were screened for BKPyV DNA and BKPyV-specific antibodies. We found that the donor BKPyV immunoglobulin G (IgG) seroprevalence and antibody level were strongly associated with BKPyV-DNAemia and BKPyVAN, although multivariant analysis found the presence of anti-BKPyV-specific antibodies as a predictive factor only for BKPyV-DNAemia. The pretransplant recipient status had no effect on posttransplant BKPyV-DNAemia and BKVAN. BKPyV IgG levels remained stable in BKPyV-negative recipients during 1-year follow-up, while a considerable increase was observed in BKPyV-positive patients. The presence of anti-BKPyV-specific antibodies in kidney allograft donors is a good and reliable predictive marker for posttransplant BKPyV replication with relevance to risk stratification in transplant recipients. Frontiers Media S.A. 2022-07-25 /pmc/articles/PMC9364833/ /pubmed/35967393 http://dx.doi.org/10.3389/fimmu.2022.929946 Text en Copyright © 2022 Saláková, Ludvíková, Hamšíková, Kolářová, Šroller, Viklický and Wohlfahrtová https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Saláková, Martina
Ludvíková, Viera
Hamšíková, Eva
Kolářová, Marie
Šroller, Vojtěch
Viklický, Ondřej
Wohlfahrtová, Mariana
Pretransplantation seroreactivity in kidney donors and recipients as a predictive factor for posttransplant BKPyV-DNAemia
title Pretransplantation seroreactivity in kidney donors and recipients as a predictive factor for posttransplant BKPyV-DNAemia
title_full Pretransplantation seroreactivity in kidney donors and recipients as a predictive factor for posttransplant BKPyV-DNAemia
title_fullStr Pretransplantation seroreactivity in kidney donors and recipients as a predictive factor for posttransplant BKPyV-DNAemia
title_full_unstemmed Pretransplantation seroreactivity in kidney donors and recipients as a predictive factor for posttransplant BKPyV-DNAemia
title_short Pretransplantation seroreactivity in kidney donors and recipients as a predictive factor for posttransplant BKPyV-DNAemia
title_sort pretransplantation seroreactivity in kidney donors and recipients as a predictive factor for posttransplant bkpyv-dnaemia
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364833/
https://www.ncbi.nlm.nih.gov/pubmed/35967393
http://dx.doi.org/10.3389/fimmu.2022.929946
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