Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis

PURPOSE: Osteoarthritis (OA) is an age-related degenerative disease associated with enhanced degradation of extracellular matrix (ECM) and decreased autophagy. Our study is aimed to explore how corosolic acid (CRA) affect cartilage ECM metabolism and the potential mechanism. METHODS: Rat chondrocyte...

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Detalles Bibliográficos
Autores principales: Han, Hui, Chen, Ming, Li, Zhenyu, Zhou, Siqi, Wu, Yingbin, Wei, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364989/
https://www.ncbi.nlm.nih.gov/pubmed/35965964
http://dx.doi.org/10.2147/DDDT.S365279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364989/
https://www.ncbi.nlm.nih.gov/pubmed/35965964
http://dx.doi.org/10.2147/DDDT.S365279

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