Atypical HUS Triggered by COVID-19: A Case Report

We hereby present a case of an atypical hemolytic uremic syndrome (aHUS) precipitated by coronavirus disease 2019 (COVID-19). A 26-year-old male was diagnosed with COVID-19 and acute kidney injury. His kidney biopsy was suggestive of thrombotic microangiopathy. Five sessions of plasmapheresis were d...

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Autores principales: Tiwari, Vaibhav, Bhandari, Gaurav, Gupta, Anurag, Gupta, Pallav, Bhargava, Vinant, Malik, Manish, Gupta, Ashwini, Bhalla, Anil K., Rana, Devinder S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364994/
https://www.ncbi.nlm.nih.gov/pubmed/35967527
http://dx.doi.org/10.4103/ijn.ijn_196_21
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author Tiwari, Vaibhav
Bhandari, Gaurav
Gupta, Anurag
Gupta, Pallav
Bhargava, Vinant
Malik, Manish
Gupta, Ashwini
Bhalla, Anil K.
Rana, Devinder S.
author_facet Tiwari, Vaibhav
Bhandari, Gaurav
Gupta, Anurag
Gupta, Pallav
Bhargava, Vinant
Malik, Manish
Gupta, Ashwini
Bhalla, Anil K.
Rana, Devinder S.
author_sort Tiwari, Vaibhav
collection PubMed
description We hereby present a case of an atypical hemolytic uremic syndrome (aHUS) precipitated by coronavirus disease 2019 (COVID-19). A 26-year-old male was diagnosed with COVID-19 and acute kidney injury. His kidney biopsy was suggestive of thrombotic microangiopathy. Five sessions of plasmapheresis were done but were discontinued in view of nonrecovery of kidney function. He was then referred for a kidney transplant. On genetic analysis, he was found to have mutations in the complement system (CFHR1 and CFHR3), which suggested this was a case of aHUS precipitated by COVID-19. In view of the high risk of recurrence of the primary disease in live-related kidney donor transplantation, he was advised for simultaneous liver and kidney transplants.
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spelling pubmed-93649942022-08-11 Atypical HUS Triggered by COVID-19: A Case Report Tiwari, Vaibhav Bhandari, Gaurav Gupta, Anurag Gupta, Pallav Bhargava, Vinant Malik, Manish Gupta, Ashwini Bhalla, Anil K. Rana, Devinder S. Indian J Nephrol Case Report We hereby present a case of an atypical hemolytic uremic syndrome (aHUS) precipitated by coronavirus disease 2019 (COVID-19). A 26-year-old male was diagnosed with COVID-19 and acute kidney injury. His kidney biopsy was suggestive of thrombotic microangiopathy. Five sessions of plasmapheresis were done but were discontinued in view of nonrecovery of kidney function. He was then referred for a kidney transplant. On genetic analysis, he was found to have mutations in the complement system (CFHR1 and CFHR3), which suggested this was a case of aHUS precipitated by COVID-19. In view of the high risk of recurrence of the primary disease in live-related kidney donor transplantation, he was advised for simultaneous liver and kidney transplants. Medknow Publications & Media Pvt Ltd 2022 2022-05-20 /pmc/articles/PMC9364994/ /pubmed/35967527 http://dx.doi.org/10.4103/ijn.ijn_196_21 Text en Copyright: © Indian Journal of Nephrology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Tiwari, Vaibhav
Bhandari, Gaurav
Gupta, Anurag
Gupta, Pallav
Bhargava, Vinant
Malik, Manish
Gupta, Ashwini
Bhalla, Anil K.
Rana, Devinder S.
Atypical HUS Triggered by COVID-19: A Case Report
title Atypical HUS Triggered by COVID-19: A Case Report
title_full Atypical HUS Triggered by COVID-19: A Case Report
title_fullStr Atypical HUS Triggered by COVID-19: A Case Report
title_full_unstemmed Atypical HUS Triggered by COVID-19: A Case Report
title_short Atypical HUS Triggered by COVID-19: A Case Report
title_sort atypical hus triggered by covid-19: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9364994/
https://www.ncbi.nlm.nih.gov/pubmed/35967527
http://dx.doi.org/10.4103/ijn.ijn_196_21
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