A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike

Neutralizing antibodies targeting the SARS-CoV-2 spike protein have shown a great preventative/therapeutic potential. Here, we report a rapid and efficient strategy for the development and design of SARS-CoV-2 neutralizing humanized nanobody constructs with sub-nanomolar affinities and nanomolar pot...

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Detalles Bibliográficos
Autores principales: Fu, Ying, da Fonseca Rezende e Mello, Juliana, Fleming, Bryan D., Renn, Alex, Chen, Catherine Z., Hu, Xin, Xu, Miao, Gorshkov, Kirill, Hanson, Quinlin, Zheng, Wei, Lee, Emily M., Perera, Lalith, Petrovich, Robert, Pradhan, Manisha, Eastman, Richard T., Itkin, Zina, Stanley, Thomas B., Hsu, Allen, Dandey, Venkata, Sharma, Kedar, Gillette, William, Taylor, Troy, Ramakrishnan, Nitya, Perkins, Shelley, Esposito, Dominic, Oh, Eunkeu, Susumu, Kimihiro, Wolak, Mason, Ferrer, Marc, Hall, Matthew D., Borgnia, Mario J., Simeonov, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365158/
https://www.ncbi.nlm.nih.gov/pubmed/35947606
http://dx.doi.org/10.1371/journal.pone.0272364

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