Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike

The spike (S) protein of SARS-CoV-2 has been observed in three distinct pre-fusion conformations: locked, closed and open. Of these, the function of the locked conformation remains poorly understood. Here we engineered a SARS-CoV-2 S protein construct “S-R/x3” to arrest SARS-CoV-2 spikes in the lock...

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Detalles Bibliográficos
Autores principales: Qu, Kun, Chen, Qiuluan, Ciazynska, Katarzyna A., Liu, Banghui, Zhang, Xixi, Wang, Jingjing, He, Yujie, Guan, Jiali, He, Jun, Liu, Tian, Zhang, Xiaofei, Carter, Andrew P., Xiong, Xiaoli, Briggs, John A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365160/
https://www.ncbi.nlm.nih.gov/pubmed/35905112
http://dx.doi.org/10.1371/journal.ppat.1010583

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