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Predictive and Therapeutic Implications of a Novel PLCγ1/SHP2-Driven Mechanism of Cetuximab Resistance in Metastatic Colorectal Cancer

PURPOSE: Cetuximab is an EGFR-targeted therapy approved for the treatment of RAS wild-type (WT) metastatic colorectal cancer (mCRC). However, about 60% of these patients show innate resistance to cetuximab. To increase cetuximab efficacy, it is crucial to successfully identify responder patients, as...

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Detalles Bibliográficos
Autores principales:	Cruz-Duarte, Raquel, Rebelo de Almeida, Cátia, Negrão, Magda, Fernandes, Afonso, Borralho, Paula, Sobral, Daniel, Gallego-Paez, Lina M., Machado, Daniel, Gramaça, João, Vílchez, José, Xavier, Ana T., Ferreira, Miguel Godinho, Miranda, Ana R., Mansinho, Helder, Brito, Maria J., Pacheco, Teresa R., Abreu, Catarina, Lucia-Costa, Ana, Mansinho, André, Fior, Rita, Costa, Luís, Martins, Marta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Translational Cancer Mechanisms and Therapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365369/ https://www.ncbi.nlm.nih.gov/pubmed/34980600 http://dx.doi.org/10.1158/1078-0432.CCR-21-1992

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