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The RIPK family: expression profile and prognostic value in lung adenocarcinoma

Receptor interacting protein kinases (RIPKs) are a family of serine/threonine kinases which are supposed to regulate tumor generation and progression. Rare study illustrates the roles and functions of RIPKs family in lung adenocarcinoma (LUAD) comprehensively. Our results indicated that the expressi...

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Autores principales: Li, Guo, Xu, Zhijie, Peng, Jinwu, Yan, Yuanliang, Liu, Yong, Zhang, Xin, Qiu, Yuanzheng, Fu, Chencheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365553/
https://www.ncbi.nlm.nih.gov/pubmed/35907206
http://dx.doi.org/10.18632/aging.204195
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author Li, Guo
Xu, Zhijie
Peng, Jinwu
Yan, Yuanliang
Liu, Yong
Zhang, Xin
Qiu, Yuanzheng
Fu, Chencheng
author_facet Li, Guo
Xu, Zhijie
Peng, Jinwu
Yan, Yuanliang
Liu, Yong
Zhang, Xin
Qiu, Yuanzheng
Fu, Chencheng
author_sort Li, Guo
collection PubMed
description Receptor interacting protein kinases (RIPKs) are a family of serine/threonine kinases which are supposed to regulate tumor generation and progression. Rare study illustrates the roles and functions of RIPKs family in lung adenocarcinoma (LUAD) comprehensively. Our results indicated that the expression of RIPK2 higher in LUAD patients while RIPK5 (encoded by gene DSTYK) expression was lower. Only RIPK2 had a strong correlation with pathological stage in LUAD patients. Kaplan-Meier plotter revealed that LUAD patients with low RIPK2 or RIPK3 level showed better overall survival (OS), but worse when LUAD patients with high RIPK5. Further, lower expression of RIPK2 and higher expression of RIPK1, RIPK4 and RIPK5 prompted a longer disease free survival (DFS). Genetic alterations based on cBioPortal revealing 16% alteration rates of RIPK2, as well as RIPK5. We also found that the functions of RIPKs family were linked to cellular senescence, protein serine/threonine kinase activity, apoptosis process et al. TIMER database indicated that the RIPKs family members had distinct relationships with the infiltration of six types of immune cells (macrophages, neutrophils, CD8+ T-cells, B-cells, CD4+ T-cells and dendritic cells). Moreover, RIPK2 could be observed as an independent prognostic factor with Cox proportional hazard model analysis. DiseaseMeth databases revealed that the global methylation levels of RIPK2 increased in LUAD patients. Thus, the findings above will enhance the understanding of RIPKs family in LUAD pathology and progression, providing novel insights into RIPKs-core therapy for LUAD patients.
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spelling pubmed-93655532022-08-11 The RIPK family: expression profile and prognostic value in lung adenocarcinoma Li, Guo Xu, Zhijie Peng, Jinwu Yan, Yuanliang Liu, Yong Zhang, Xin Qiu, Yuanzheng Fu, Chencheng Aging (Albany NY) Research Paper Receptor interacting protein kinases (RIPKs) are a family of serine/threonine kinases which are supposed to regulate tumor generation and progression. Rare study illustrates the roles and functions of RIPKs family in lung adenocarcinoma (LUAD) comprehensively. Our results indicated that the expression of RIPK2 higher in LUAD patients while RIPK5 (encoded by gene DSTYK) expression was lower. Only RIPK2 had a strong correlation with pathological stage in LUAD patients. Kaplan-Meier plotter revealed that LUAD patients with low RIPK2 or RIPK3 level showed better overall survival (OS), but worse when LUAD patients with high RIPK5. Further, lower expression of RIPK2 and higher expression of RIPK1, RIPK4 and RIPK5 prompted a longer disease free survival (DFS). Genetic alterations based on cBioPortal revealing 16% alteration rates of RIPK2, as well as RIPK5. We also found that the functions of RIPKs family were linked to cellular senescence, protein serine/threonine kinase activity, apoptosis process et al. TIMER database indicated that the RIPKs family members had distinct relationships with the infiltration of six types of immune cells (macrophages, neutrophils, CD8+ T-cells, B-cells, CD4+ T-cells and dendritic cells). Moreover, RIPK2 could be observed as an independent prognostic factor with Cox proportional hazard model analysis. DiseaseMeth databases revealed that the global methylation levels of RIPK2 increased in LUAD patients. Thus, the findings above will enhance the understanding of RIPKs family in LUAD pathology and progression, providing novel insights into RIPKs-core therapy for LUAD patients. Impact Journals 2022-07-30 /pmc/articles/PMC9365553/ /pubmed/35907206 http://dx.doi.org/10.18632/aging.204195 Text en Copyright: © 2022 Li et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Li, Guo
Xu, Zhijie
Peng, Jinwu
Yan, Yuanliang
Liu, Yong
Zhang, Xin
Qiu, Yuanzheng
Fu, Chencheng
The RIPK family: expression profile and prognostic value in lung adenocarcinoma
title The RIPK family: expression profile and prognostic value in lung adenocarcinoma
title_full The RIPK family: expression profile and prognostic value in lung adenocarcinoma
title_fullStr The RIPK family: expression profile and prognostic value in lung adenocarcinoma
title_full_unstemmed The RIPK family: expression profile and prognostic value in lung adenocarcinoma
title_short The RIPK family: expression profile and prognostic value in lung adenocarcinoma
title_sort ripk family: expression profile and prognostic value in lung adenocarcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365553/
https://www.ncbi.nlm.nih.gov/pubmed/35907206
http://dx.doi.org/10.18632/aging.204195
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