Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity

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Kinesin-1 activity is regulated by autoinhibition. Intramolecular interactions within the kinesin heavy chain (KHC) are proposed to be one facet of motor regulation. The KHC also binds to the kinesin light chain (KLC), which has been implicated in both autoinhibition and activation of the motor. We...

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Detalles Bibliográficos
Autores principales: Chiba, Kyoko, Ori-McKenney, Kassandra M., Niwa, Shinsuke, McKenney, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365671/
https://www.ncbi.nlm.nih.gov/pubmed/35649356
http://dx.doi.org/10.1016/j.celrep.2022.110900

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