Cargando…
Investigation of [(3)H]diazepam derivatives as allosteric modulators of GABAA receptor α(1)β(2)γ(2) subtypes: combination of molecular docking/dynamic simulations, pharmacokinetics/drug-likeness prediction, and QSAR analysis
In this paper, a data set of [(3)H] diazepam derivatives was analyzed using various computational methods: molecular docking/dynamic simulations, and QSAR analysis. The main aims of these studies are to understand the binding mechanisms by which benzodiazepines allosterically modulate GABA(A) recept...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365687/ https://www.ncbi.nlm.nih.gov/pubmed/35971551 http://dx.doi.org/10.1007/s11224-022-02029-4 |