The combination of gene hyperamplification and PD-L1 expression as a biomarker for the clinical benefit of tislelizumab in gastric/gastroesophageal junction adenocarcinoma

BACKGROUND: In solid tumor Phase 1/2 trials (NCT02407990; NCT04068519), tislelizumab demonstrated clinical benefit, including in advanced gastroesophageal adenocarcinoma (GEA). However, the majority of patients with GEA did not respond, highlighting the need to understand mechanisms of resistance an...

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Detalles Bibliográficos
Autores principales: Lu, Zhihao, Yang, Silu, Luo, Xuerui, Shi, Yang, Lee, Jong-Seok, Deva, Sanjeev, Liu, Tianshu, Chao, Yee, Zhang, Yun, Huang, Ruiqi, Xu, Yaling, Shen, Zhirong, Shen, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365737/
https://www.ncbi.nlm.nih.gov/pubmed/35778636
http://dx.doi.org/10.1007/s10120-022-01308-7

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