Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT

Huntington’s disease is a neurodegenerative disease caused by an expanded polyQ stretch within Huntingtin (HTT) that renders the protein aggregation-prone, ultimately resulting in the formation of amyloid fibrils. A trimeric chaperone complex composed of Hsc70, DNAJB1 and Apg2 can suppress and rever...

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Detalles Bibliográficos
Autores principales: Ayala Mariscal, S. M., Pigazzini, M. L., Richter, Y., Özel, M., Grothaus, I. L., Protze, J., Ziege, K., Kulke, M., ElBediwi, M., Vermaas, J. V., Colombi Ciacchi, L., Köppen, S., Liu, F., Kirstein, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365803/
https://www.ncbi.nlm.nih.gov/pubmed/35948542
http://dx.doi.org/10.1038/s41467-022-32370-5

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