Neuronal congruency effects in macaque prefrontal cortex

The interplay between task-relevant and task-irrelevant information may induce conflicts that impair behavioral performance, a.k.a. behavioral congruency effects. The neuronal mechanisms underlying behavioral congruency effects, however, are poorly understood. We recorded single unit activity in monkey prefrontal cortex using a task-switching paradigm and discovered a neuronal congruency effect (NCE) that is carried by target and distractor neurons which process target and distractor-related information, respectively. The former neurons provide more signal, the latter less noise in congruent compared to incongruent conditions, resulting in a better target representation. Such NCE is dominated by the level of congruency, and is not determined by the task rules the subjects used, their reaction times (RT), the length of the delay period, nor the response levels of the neurons. We propose that this NCE can explain behavioral congruency effects in general, as well as previous fMRI and EEG results in various conflict paradigms.