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The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults
The recently discovered truncated, non-functional, ACE2 transcript (dACE2), but not the full-length ACE2 (f-lACE2), is induced by IFNs in differentiated airway cells. We measured expression of both ACE2 isoforms in SARS-CoV-2 positive and negative subjects, in relation to Interferon-stimulated genes...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365862/ https://www.ncbi.nlm.nih.gov/pubmed/35969900 http://dx.doi.org/10.1016/j.cyto.2022.155997 |
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| author | Oliveto, Giuseppe Scagnolari, Carolina Frasca, Federica Sorrentino, Leonardo Matera, Luigi Nenna, Raffaella Viscido, Agnese Scordio, Mirko Petrarca, Laura Maria Zicari, Anna Gentilini, Elio D'Ettorre, Gabriella Ceccarelli, Giancarlo Midulla, Fabio Antonelli, Guido Pierangeli, Alessandra |
| author_facet | Oliveto, Giuseppe Scagnolari, Carolina Frasca, Federica Sorrentino, Leonardo Matera, Luigi Nenna, Raffaella Viscido, Agnese Scordio, Mirko Petrarca, Laura Maria Zicari, Anna Gentilini, Elio D'Ettorre, Gabriella Ceccarelli, Giancarlo Midulla, Fabio Antonelli, Guido Pierangeli, Alessandra |
| author_sort | Oliveto, Giuseppe |
| collection | PubMed |
| description | The recently discovered truncated, non-functional, ACE2 transcript (dACE2), but not the full-length ACE2 (f-lACE2), is induced by IFNs in differentiated airway cells. We measured expression of both ACE2 isoforms in SARS-CoV-2 positive and negative subjects, in relation to Interferon-stimulated genes. A significant activation of dACE2 transcript was found, in SARS-CoV-2 positive adults either hospitalized or not, showing a positive correlation with ISG15; f-lACE2 expression was weakly activated and not ISG-related. We confirmed a specific activation of dACE2 transcript in nasopharyngeal cells, related to the mucosal IFN response. |
| format | Online Article Text |
| id | pubmed-9365862 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier Ltd. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-93658622022-08-11 The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults Oliveto, Giuseppe Scagnolari, Carolina Frasca, Federica Sorrentino, Leonardo Matera, Luigi Nenna, Raffaella Viscido, Agnese Scordio, Mirko Petrarca, Laura Maria Zicari, Anna Gentilini, Elio D'Ettorre, Gabriella Ceccarelli, Giancarlo Midulla, Fabio Antonelli, Guido Pierangeli, Alessandra Cytokine Article The recently discovered truncated, non-functional, ACE2 transcript (dACE2), but not the full-length ACE2 (f-lACE2), is induced by IFNs in differentiated airway cells. We measured expression of both ACE2 isoforms in SARS-CoV-2 positive and negative subjects, in relation to Interferon-stimulated genes. A significant activation of dACE2 transcript was found, in SARS-CoV-2 positive adults either hospitalized or not, showing a positive correlation with ISG15; f-lACE2 expression was weakly activated and not ISG-related. We confirmed a specific activation of dACE2 transcript in nasopharyngeal cells, related to the mucosal IFN response. Elsevier Ltd. 2022-10 2022-08-11 /pmc/articles/PMC9365862/ /pubmed/35969900 http://dx.doi.org/10.1016/j.cyto.2022.155997 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Article Oliveto, Giuseppe Scagnolari, Carolina Frasca, Federica Sorrentino, Leonardo Matera, Luigi Nenna, Raffaella Viscido, Agnese Scordio, Mirko Petrarca, Laura Maria Zicari, Anna Gentilini, Elio D'Ettorre, Gabriella Ceccarelli, Giancarlo Midulla, Fabio Antonelli, Guido Pierangeli, Alessandra The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults |
| title | The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults |
| title_full | The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults |
| title_fullStr | The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults |
| title_full_unstemmed | The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults |
| title_short | The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults |
| title_sort | non-functional ace2 isoform, but not the sars-cov-2 receptor, is induced as an interferon-stimulated gene, in sars-cov-2 infected adults |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365862/ https://www.ncbi.nlm.nih.gov/pubmed/35969900 http://dx.doi.org/10.1016/j.cyto.2022.155997 |
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