The non-functional ACE2 isoform, but not the SARS-CoV-2 receptor, is induced as an interferon-stimulated gene, in SARS-CoV-2 infected adults

The recently discovered truncated, non-functional, ACE2 transcript (dACE2), but not the full-length ACE2 (f-lACE2), is induced by IFNs in differentiated airway cells. We measured expression of both ACE2 isoforms in SARS-CoV-2 positive and negative subjects, in relation to Interferon-stimulated genes...

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Detalles Bibliográficos
Autores principales: Oliveto, Giuseppe, Scagnolari, Carolina, Frasca, Federica, Sorrentino, Leonardo, Matera, Luigi, Nenna, Raffaella, Viscido, Agnese, Scordio, Mirko, Petrarca, Laura, Maria Zicari, Anna, Gentilini, Elio, D'Ettorre, Gabriella, Ceccarelli, Giancarlo, Midulla, Fabio, Antonelli, Guido, Pierangeli, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365862/
https://www.ncbi.nlm.nih.gov/pubmed/35969900
http://dx.doi.org/10.1016/j.cyto.2022.155997

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