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Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites

The SARS-CoV-2 3CL protease (3CL(pro)) is an attractive therapeutic target, as it is essential to the virus and highly conserved among coronaviruses. However, our current understanding of its tolerance to mutations is limited. Here, we develop a yeast-based deep mutational scanning approach to syste...

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Detalles Bibliográficos
Autores principales:	Iketani, Sho, Hong, Seo Jung, Sheng, Jenny, Bahari, Farideh, Culbertson, Bruce, Atanaki, Fereshteh Fallah, Aditham, Arjun K., Kratz, Alexander F., Luck, Maria I., Tian, Ruxiao, Goff, Stephen P., Montazeri, Hesam, Sabo, Yosef, Ho, David D., Chavez, Alejandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2022
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365866/ https://www.ncbi.nlm.nih.gov/pubmed/36029764 http://dx.doi.org/10.1016/j.chom.2022.08.003

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