Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD), an X-linked disorder caused by loss-of-function mutations in the dystrophin gene, is characterized by progressive muscle degeneration and weakness. Enhanced store-operated Ca(2+) entry (SOCE), a Ca(2+) influx mechanism coordinated by STIM1 sensors of luminal Ca(2+)...

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Detalles Bibliográficos
Autores principales: García-Castañeda, Maricela, Michelucci, Antonio, Zhao, Nan, Malik, Sundeep, Dirksen, Robert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365874/
https://www.ncbi.nlm.nih.gov/pubmed/35939054
http://dx.doi.org/10.1085/jgp.202213081

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