IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2

Humoral immunity to SARS-CoV-2 can be supplemented with polyclonal sera from convalescent donors or an engineered monoclonal antibody (mAb) product. While pentameric IgM antibodies are responsible for much of convalescent sera’s neutralizing capacity, all available mAbs are based on the monomeric Ig...

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Detalles Bibliográficos
Autores principales: Hale, Malika, Netland, Jason, Chen, Yu, Thouvenel, Christopher D., Smith, Katherine Nabel, Rich, Lucille M., Vanderwall, Elizabeth R., Miranda, Marcos C., Eggenberger, Julie, Hao, Linhui, Watson, Michael J., Mundorff, Charles C., Rodda, Lauren B., King, Neil P., Guttman, Miklos, Gale, Michael, Abraham, Jonathan, Debley, Jason S., Pepper, Marion, Rawlings, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365875/
https://www.ncbi.nlm.nih.gov/pubmed/35938988
http://dx.doi.org/10.1084/jem.20220849

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