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Neurogenic mechanisms for locomotor-respiratory coordination in mammals

Central motor rhythm-generating networks controlling different functions are generally considered to operate mostly independently from one another, each controlling the specific behavioral task to which it is assigned. However, under certain physiological circumstances, central pattern generators (C...

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Autores principales: Juvin, Laurent, Colnot, Eloïse, Barrière, Grégory, Thoby-Brisson, Muriel, Morin, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365938/
https://www.ncbi.nlm.nih.gov/pubmed/35968158
http://dx.doi.org/10.3389/fnana.2022.953746
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author Juvin, Laurent
Colnot, Eloïse
Barrière, Grégory
Thoby-Brisson, Muriel
Morin, Didier
author_facet Juvin, Laurent
Colnot, Eloïse
Barrière, Grégory
Thoby-Brisson, Muriel
Morin, Didier
author_sort Juvin, Laurent
collection PubMed
description Central motor rhythm-generating networks controlling different functions are generally considered to operate mostly independently from one another, each controlling the specific behavioral task to which it is assigned. However, under certain physiological circumstances, central pattern generators (CPGs) can exhibit strong uni- or bidirectional interactions that render them closely inter-dependent. One of the best illustrations of such an inter-CPG interaction is the functional relationship that may occur between rhythmic locomotor and respiratory functions. It is well known that in vertebrates, lung ventilatory rates accelerate at the onset of physical exercise in order to satisfy the accompanying rapid increase in metabolism. Part of this acceleration is sustained by a coupling between locomotion and ventilation, which most often results in a periodic drive of the respiratory cycle by the locomotor rhythm. In terrestrial vertebrates, the likely physiological significance of this coordination is that it serves to reduce the mechanical interference between the two motor systems, thereby producing an energetic benefit and ultimately, enabling sustained aerobic activity. Several decades of studies have shown that locomotor-respiratory coupling is present in most species, independent of the mode of locomotion employed. The present article aims to review and discuss mechanisms engaged in shaping locomotor-respiratory coupling (LRC), with an emphasis on the role of sensory feedback inputs, the direct influences between CPG networks themselves, and finally on spinal cellular candidates that are potentially involved in the coupling of these two vital motor functions.
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spelling pubmed-93659382022-08-12 Neurogenic mechanisms for locomotor-respiratory coordination in mammals Juvin, Laurent Colnot, Eloïse Barrière, Grégory Thoby-Brisson, Muriel Morin, Didier Front Neuroanat Neuroscience Central motor rhythm-generating networks controlling different functions are generally considered to operate mostly independently from one another, each controlling the specific behavioral task to which it is assigned. However, under certain physiological circumstances, central pattern generators (CPGs) can exhibit strong uni- or bidirectional interactions that render them closely inter-dependent. One of the best illustrations of such an inter-CPG interaction is the functional relationship that may occur between rhythmic locomotor and respiratory functions. It is well known that in vertebrates, lung ventilatory rates accelerate at the onset of physical exercise in order to satisfy the accompanying rapid increase in metabolism. Part of this acceleration is sustained by a coupling between locomotion and ventilation, which most often results in a periodic drive of the respiratory cycle by the locomotor rhythm. In terrestrial vertebrates, the likely physiological significance of this coordination is that it serves to reduce the mechanical interference between the two motor systems, thereby producing an energetic benefit and ultimately, enabling sustained aerobic activity. Several decades of studies have shown that locomotor-respiratory coupling is present in most species, independent of the mode of locomotion employed. The present article aims to review and discuss mechanisms engaged in shaping locomotor-respiratory coupling (LRC), with an emphasis on the role of sensory feedback inputs, the direct influences between CPG networks themselves, and finally on spinal cellular candidates that are potentially involved in the coupling of these two vital motor functions. Frontiers Media S.A. 2022-07-28 /pmc/articles/PMC9365938/ /pubmed/35968158 http://dx.doi.org/10.3389/fnana.2022.953746 Text en Copyright © 2022 Juvin, Colnot, Barrière, Thoby-Brisson and Morin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Juvin, Laurent
Colnot, Eloïse
Barrière, Grégory
Thoby-Brisson, Muriel
Morin, Didier
Neurogenic mechanisms for locomotor-respiratory coordination in mammals
title Neurogenic mechanisms for locomotor-respiratory coordination in mammals
title_full Neurogenic mechanisms for locomotor-respiratory coordination in mammals
title_fullStr Neurogenic mechanisms for locomotor-respiratory coordination in mammals
title_full_unstemmed Neurogenic mechanisms for locomotor-respiratory coordination in mammals
title_short Neurogenic mechanisms for locomotor-respiratory coordination in mammals
title_sort neurogenic mechanisms for locomotor-respiratory coordination in mammals
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365938/
https://www.ncbi.nlm.nih.gov/pubmed/35968158
http://dx.doi.org/10.3389/fnana.2022.953746
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