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Systemic immune effects of anesthetics and their intracellular targets in tumors

According to the result released by the World Health Organization (WHO), non-communicable diseases have occupied four of the top 10 current causes for death in the world. Cancer is one of the significant factors that trigger complications and deaths; more than 80% cancer patients require surgical or...

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Autores principales: Luan, Ting, Li, Yi, Sun, Lihui, Xu, Siqi, Wang, Haifeng, Wang, Jiansong, Li, Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365985/
https://www.ncbi.nlm.nih.gov/pubmed/35966857
http://dx.doi.org/10.3389/fmed.2022.810189
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author Luan, Ting
Li, Yi
Sun, Lihui
Xu, Siqi
Wang, Haifeng
Wang, Jiansong
Li, Chong
author_facet Luan, Ting
Li, Yi
Sun, Lihui
Xu, Siqi
Wang, Haifeng
Wang, Jiansong
Li, Chong
author_sort Luan, Ting
collection PubMed
description According to the result released by the World Health Organization (WHO), non-communicable diseases have occupied four of the top 10 current causes for death in the world. Cancer is one of the significant factors that trigger complications and deaths; more than 80% cancer patients require surgical or palliative treatment. In this case, anesthetic treatment is indispensable. Since cancer is a heterogeneous disease, various types of interventions can activate oncogenes or mutate tumor suppressor genes. More and more researchers believe that anesthetics have a certain effect on the long-term recurrence and metastasis of tumors, but it is still controversial whether they promote or inhibit the progression of cancer. On this basis, a series of retrospective or prospective randomized clinical trials have been conducted, but it seems to be difficult to reach a conclusion within 5 years or longer. This article focuses on the effects of anesthetic drugs on immune function and cancer and reviews their latest targets on the tumor cells, in order to provide a theoretical basis for optimizing the selection of anesthetic drugs, exploring therapeutic targets, and improving the prognosis of cancer patients.
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spelling pubmed-93659852022-08-12 Systemic immune effects of anesthetics and their intracellular targets in tumors Luan, Ting Li, Yi Sun, Lihui Xu, Siqi Wang, Haifeng Wang, Jiansong Li, Chong Front Med (Lausanne) Medicine According to the result released by the World Health Organization (WHO), non-communicable diseases have occupied four of the top 10 current causes for death in the world. Cancer is one of the significant factors that trigger complications and deaths; more than 80% cancer patients require surgical or palliative treatment. In this case, anesthetic treatment is indispensable. Since cancer is a heterogeneous disease, various types of interventions can activate oncogenes or mutate tumor suppressor genes. More and more researchers believe that anesthetics have a certain effect on the long-term recurrence and metastasis of tumors, but it is still controversial whether they promote or inhibit the progression of cancer. On this basis, a series of retrospective or prospective randomized clinical trials have been conducted, but it seems to be difficult to reach a conclusion within 5 years or longer. This article focuses on the effects of anesthetic drugs on immune function and cancer and reviews their latest targets on the tumor cells, in order to provide a theoretical basis for optimizing the selection of anesthetic drugs, exploring therapeutic targets, and improving the prognosis of cancer patients. Frontiers Media S.A. 2022-07-28 /pmc/articles/PMC9365985/ /pubmed/35966857 http://dx.doi.org/10.3389/fmed.2022.810189 Text en Copyright © 2022 Luan, Li, Sun, Xu, Wang, Wang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Luan, Ting
Li, Yi
Sun, Lihui
Xu, Siqi
Wang, Haifeng
Wang, Jiansong
Li, Chong
Systemic immune effects of anesthetics and their intracellular targets in tumors
title Systemic immune effects of anesthetics and their intracellular targets in tumors
title_full Systemic immune effects of anesthetics and their intracellular targets in tumors
title_fullStr Systemic immune effects of anesthetics and their intracellular targets in tumors
title_full_unstemmed Systemic immune effects of anesthetics and their intracellular targets in tumors
title_short Systemic immune effects of anesthetics and their intracellular targets in tumors
title_sort systemic immune effects of anesthetics and their intracellular targets in tumors
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365985/
https://www.ncbi.nlm.nih.gov/pubmed/35966857
http://dx.doi.org/10.3389/fmed.2022.810189
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