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Small molecules to regulate the GH/IGF1 axis by inhibiting the growth hormone receptor synthesis

Growth hormone (GH) and insulin‐like growth factor‐1 (IGF1) play an important role in mammalian development, cell proliferation and lifespan. Especially in cases of tumor growth there is an urgent need to control the GH/IGF1 axis. In this study we screened a 38,480-compound library, and in two conse...

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Detalles Bibliográficos
Autores principales:	van der Velden, Lieke M., Maas, Peter, van Amersfoort, Miranda, Timmermans-Sprang, Elpetra P M., Mensinga, Anneloes, van der Vaart, Elisabeth, Malergue, Fabrice, Viëtor, Henk, Derksen, Patrick W B., Klumperman, Judith, van Agthoven, Andreas, Egan, David A., Mol, Jan A., Strous, Ger J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365994/ https://www.ncbi.nlm.nih.gov/pubmed/35966052 http://dx.doi.org/10.3389/fendo.2022.926210

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