Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors

Adenosine triphosphate (ATP) released from injured or dying cells is a potent pro-inflammatory “danger” signal. Alkaline phosphatase (AP), an endogenous enzyme that de-phosphorylates extracellular ATP, likely plays an anti-inflammatory role in immune responses. We hypothesized that ilofotase alfa, a...

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Detalles Bibliográficos
Autores principales: Rosin, Diane L., Hall, J. Perry, Zheng, Shuqiu, Huang, Liping, Campos-Bilderback, Silvia, Sandoval, Ruben, Bree, Andrea, Beaumont, Kevin, Miller, Emily, Larsen, Jennifer, Hariri, Ghazal, Kaila, Neelu, Encarnacion, Iain M., Gale, Jeremy D., van Elsas, Andrea, Molitoris, Bruce A., Okusa, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366018/
https://www.ncbi.nlm.nih.gov/pubmed/35966871
http://dx.doi.org/10.3389/fmed.2022.931293

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