Potential roles of non-lymphocytic cells in the pathogenesis of IgG4-related disease

Studies have confirmed the involvement of a variety of lymphocyte subsets, including type 2 helper T lymphocytes (Th2) and IgG4(+) B lymphocytes, in the pathogenesis of IgG4-related disease (IgG4-RD). Those lymphocytes contribute to the major pathogenetic features of IgG4-RD. However, they are not t...

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Autores principales: Cai, Shaozhe, Hu, Ziwei, Chen, Yu, Zhong, Jixin, Dong, Lingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366038/
https://www.ncbi.nlm.nih.gov/pubmed/35967331
http://dx.doi.org/10.3389/fimmu.2022.940581
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author Cai, Shaozhe
Hu, Ziwei
Chen, Yu
Zhong, Jixin
Dong, Lingli
author_facet Cai, Shaozhe
Hu, Ziwei
Chen, Yu
Zhong, Jixin
Dong, Lingli
author_sort Cai, Shaozhe
collection PubMed
description Studies have confirmed the involvement of a variety of lymphocyte subsets, including type 2 helper T lymphocytes (Th2) and IgG4(+) B lymphocytes, in the pathogenesis of IgG4-related disease (IgG4-RD). Those lymphocytes contribute to the major pathogenetic features of IgG4-RD. However, they are not the only cellular components in the immunoinflammatory environment of this mysterious disease entity. Recent studies have suggested that various non-lymphocytic components, including macrophages and fibroblasts, may also play an important role in the pathogenetic process of IgG4-RD in terms of contributing to the chronic and complex progress of the disease. Therefore, the potential role of non-lymphocyte in the pathogenesis of IgG4-RD is worth discussing.
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spelling pubmed-93660382022-08-12 Potential roles of non-lymphocytic cells in the pathogenesis of IgG4-related disease Cai, Shaozhe Hu, Ziwei Chen, Yu Zhong, Jixin Dong, Lingli Front Immunol Immunology Studies have confirmed the involvement of a variety of lymphocyte subsets, including type 2 helper T lymphocytes (Th2) and IgG4(+) B lymphocytes, in the pathogenesis of IgG4-related disease (IgG4-RD). Those lymphocytes contribute to the major pathogenetic features of IgG4-RD. However, they are not the only cellular components in the immunoinflammatory environment of this mysterious disease entity. Recent studies have suggested that various non-lymphocytic components, including macrophages and fibroblasts, may also play an important role in the pathogenetic process of IgG4-RD in terms of contributing to the chronic and complex progress of the disease. Therefore, the potential role of non-lymphocyte in the pathogenesis of IgG4-RD is worth discussing. Frontiers Media S.A. 2022-07-28 /pmc/articles/PMC9366038/ /pubmed/35967331 http://dx.doi.org/10.3389/fimmu.2022.940581 Text en Copyright © 2022 Cai, Hu, Chen, Zhong and Dong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Cai, Shaozhe
Hu, Ziwei
Chen, Yu
Zhong, Jixin
Dong, Lingli
Potential roles of non-lymphocytic cells in the pathogenesis of IgG4-related disease
title Potential roles of non-lymphocytic cells in the pathogenesis of IgG4-related disease
title_full Potential roles of non-lymphocytic cells in the pathogenesis of IgG4-related disease
title_fullStr Potential roles of non-lymphocytic cells in the pathogenesis of IgG4-related disease
title_full_unstemmed Potential roles of non-lymphocytic cells in the pathogenesis of IgG4-related disease
title_short Potential roles of non-lymphocytic cells in the pathogenesis of IgG4-related disease
title_sort potential roles of non-lymphocytic cells in the pathogenesis of igg4-related disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366038/
https://www.ncbi.nlm.nih.gov/pubmed/35967331
http://dx.doi.org/10.3389/fimmu.2022.940581
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