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High secondary attack rate and persistence of SARS-CoV-2 antibodies in household transmission study participants, Finland 2020–2021
BACKGROUND: Household transmission studies offer the opportunity to assess both secondary attack rate (SAR) and persistence of SARS-CoV-2 antibodies over time. METHODS: In Spring 2020, we invited confirmed COVID-19 cases and their household members to four visits, where we collected nasopharyngeal a...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366099/ https://www.ncbi.nlm.nih.gov/pubmed/35966873 http://dx.doi.org/10.3389/fmed.2022.876532 |
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author | Dub, Timothée Solastie, Anna Hagberg, Lotta Liedes, Oona Nohynek, Hanna Haveri, Anu Virta, Camilla Vara, Saimi Lasander, Mervi Ekström, Nina Österlund, Pamela Lind, Katja Valtonen, Hanna Hemmilä, Heidi Ikonen, Niina Lukkarinen, Timo Palmu, Arto A. Melin, Merit |
author_facet | Dub, Timothée Solastie, Anna Hagberg, Lotta Liedes, Oona Nohynek, Hanna Haveri, Anu Virta, Camilla Vara, Saimi Lasander, Mervi Ekström, Nina Österlund, Pamela Lind, Katja Valtonen, Hanna Hemmilä, Heidi Ikonen, Niina Lukkarinen, Timo Palmu, Arto A. Melin, Merit |
author_sort | Dub, Timothée |
collection | PubMed |
description | BACKGROUND: Household transmission studies offer the opportunity to assess both secondary attack rate (SAR) and persistence of SARS-CoV-2 antibodies over time. METHODS: In Spring 2020, we invited confirmed COVID-19 cases and their household members to four visits, where we collected nasopharyngeal and serum samples over 28 days after index case onset. We calculated SAR based on the presence of SARS-CoV-2 neutralizing antibodies (NAb) and assessed the persistence of NAb and IgG antibodies (Ab) against SARS-CoV-2 spike glycoprotein and nucleoprotein. RESULTS: SAR was 45% (39/87), including 35 symptomatic secondary cases. During the initial 28-day follow-up, 62% (80/129) of participants developed NAb. Of those that seroconverted, 90% (63/70), 85% (63/74), and 78% (45/58) still had NAb to early B-lineage SARS-CoV-2 3, 6, and 12 months after the onset of the index case. Anti-spike IgG Ab persisted in 100% (69/69), 97% (72/74), and 93% (55/59) of seroconverted participants after 3, 6, and 12 months, while anti-nucleoprotein IgG Ab levels waned faster, persisting in 99% (68/69), 78% (58/74), and 55% (39/71) of participants, respectively. CONCLUSION: Following detection of a COVID-19 case in a household, other members had a high risk of becoming infected. NAb to early B-lineage SARS-CoV-2 persisted for at least a year in most cases. |
format | Online Article Text |
id | pubmed-9366099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93660992022-08-12 High secondary attack rate and persistence of SARS-CoV-2 antibodies in household transmission study participants, Finland 2020–2021 Dub, Timothée Solastie, Anna Hagberg, Lotta Liedes, Oona Nohynek, Hanna Haveri, Anu Virta, Camilla Vara, Saimi Lasander, Mervi Ekström, Nina Österlund, Pamela Lind, Katja Valtonen, Hanna Hemmilä, Heidi Ikonen, Niina Lukkarinen, Timo Palmu, Arto A. Melin, Merit Front Med (Lausanne) Medicine BACKGROUND: Household transmission studies offer the opportunity to assess both secondary attack rate (SAR) and persistence of SARS-CoV-2 antibodies over time. METHODS: In Spring 2020, we invited confirmed COVID-19 cases and their household members to four visits, where we collected nasopharyngeal and serum samples over 28 days after index case onset. We calculated SAR based on the presence of SARS-CoV-2 neutralizing antibodies (NAb) and assessed the persistence of NAb and IgG antibodies (Ab) against SARS-CoV-2 spike glycoprotein and nucleoprotein. RESULTS: SAR was 45% (39/87), including 35 symptomatic secondary cases. During the initial 28-day follow-up, 62% (80/129) of participants developed NAb. Of those that seroconverted, 90% (63/70), 85% (63/74), and 78% (45/58) still had NAb to early B-lineage SARS-CoV-2 3, 6, and 12 months after the onset of the index case. Anti-spike IgG Ab persisted in 100% (69/69), 97% (72/74), and 93% (55/59) of seroconverted participants after 3, 6, and 12 months, while anti-nucleoprotein IgG Ab levels waned faster, persisting in 99% (68/69), 78% (58/74), and 55% (39/71) of participants, respectively. CONCLUSION: Following detection of a COVID-19 case in a household, other members had a high risk of becoming infected. NAb to early B-lineage SARS-CoV-2 persisted for at least a year in most cases. Frontiers Media S.A. 2022-07-28 /pmc/articles/PMC9366099/ /pubmed/35966873 http://dx.doi.org/10.3389/fmed.2022.876532 Text en Copyright © 2022 Dub, Solastie, Hagberg, Liedes, Nohynek, Haveri, Virta, Vara, Lasander, Ekström, Österlund, Lind, Valtonen, Hemmilä, Ikonen, Lukkarinen, Palmu and Melin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Dub, Timothée Solastie, Anna Hagberg, Lotta Liedes, Oona Nohynek, Hanna Haveri, Anu Virta, Camilla Vara, Saimi Lasander, Mervi Ekström, Nina Österlund, Pamela Lind, Katja Valtonen, Hanna Hemmilä, Heidi Ikonen, Niina Lukkarinen, Timo Palmu, Arto A. Melin, Merit High secondary attack rate and persistence of SARS-CoV-2 antibodies in household transmission study participants, Finland 2020–2021 |
title | High secondary attack rate and persistence of SARS-CoV-2 antibodies in household transmission study participants, Finland 2020–2021 |
title_full | High secondary attack rate and persistence of SARS-CoV-2 antibodies in household transmission study participants, Finland 2020–2021 |
title_fullStr | High secondary attack rate and persistence of SARS-CoV-2 antibodies in household transmission study participants, Finland 2020–2021 |
title_full_unstemmed | High secondary attack rate and persistence of SARS-CoV-2 antibodies in household transmission study participants, Finland 2020–2021 |
title_short | High secondary attack rate and persistence of SARS-CoV-2 antibodies in household transmission study participants, Finland 2020–2021 |
title_sort | high secondary attack rate and persistence of sars-cov-2 antibodies in household transmission study participants, finland 2020–2021 |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366099/ https://www.ncbi.nlm.nih.gov/pubmed/35966873 http://dx.doi.org/10.3389/fmed.2022.876532 |
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