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Stepwise establishment of functional microbial groups in the infant gut between 6 months and 2 years: A prospective cohort study

The early intestinal colonization of functional microbial groups plays an essential role in infant gut health, with most studies targeting the initial colonization period from birth to 6 months of age. In a previous report, we demonstrated the metabolic cross-feeding of lactate and identified keysto...

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Autores principales: Pham, Van T., Greppi, Anna, Chassard, Christophe, Braegger, Christian, Lacroix, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366138/
https://www.ncbi.nlm.nih.gov/pubmed/35967780
http://dx.doi.org/10.3389/fnut.2022.948131
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author Pham, Van T.
Greppi, Anna
Chassard, Christophe
Braegger, Christian
Lacroix, Christophe
author_facet Pham, Van T.
Greppi, Anna
Chassard, Christophe
Braegger, Christian
Lacroix, Christophe
author_sort Pham, Van T.
collection PubMed
description The early intestinal colonization of functional microbial groups plays an essential role in infant gut health, with most studies targeting the initial colonization period from birth to 6 months of age. In a previous report, we demonstrated the metabolic cross-feeding of lactate and identified keystone species specified for lactate utilization in fecal samples of 40 healthy infants. We present here the extension of our longitudinal study for the period from 6 months to 2 years, with a focus on the colonization of functional groups involved in lactate metabolism and butyrate production. We captured the dynamic changes of the gut microbiota and reported a switch in the predominant lactate-producing and lactate-utilizing bacteria, from Veillonella producing propionate in the first year to Anaerobutyrycum hallii producing butyrate in the second year of life. The significant increase in butyrate producers and fecal butyrate concentration was also pinpointed to the weaning period between 6 and 10 months. Correlation analyses further suggested, for the first time, the metabolic cross-feeding of hydrogen in infants. In conclusion, our longitudinal study of 40 Swiss infants provides important insights into the colonization of functional groups involved in lactate metabolism and butyrate production in the first 2 years of life.
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spelling pubmed-93661382022-08-12 Stepwise establishment of functional microbial groups in the infant gut between 6 months and 2 years: A prospective cohort study Pham, Van T. Greppi, Anna Chassard, Christophe Braegger, Christian Lacroix, Christophe Front Nutr Nutrition The early intestinal colonization of functional microbial groups plays an essential role in infant gut health, with most studies targeting the initial colonization period from birth to 6 months of age. In a previous report, we demonstrated the metabolic cross-feeding of lactate and identified keystone species specified for lactate utilization in fecal samples of 40 healthy infants. We present here the extension of our longitudinal study for the period from 6 months to 2 years, with a focus on the colonization of functional groups involved in lactate metabolism and butyrate production. We captured the dynamic changes of the gut microbiota and reported a switch in the predominant lactate-producing and lactate-utilizing bacteria, from Veillonella producing propionate in the first year to Anaerobutyrycum hallii producing butyrate in the second year of life. The significant increase in butyrate producers and fecal butyrate concentration was also pinpointed to the weaning period between 6 and 10 months. Correlation analyses further suggested, for the first time, the metabolic cross-feeding of hydrogen in infants. In conclusion, our longitudinal study of 40 Swiss infants provides important insights into the colonization of functional groups involved in lactate metabolism and butyrate production in the first 2 years of life. Frontiers Media S.A. 2022-07-28 /pmc/articles/PMC9366138/ /pubmed/35967780 http://dx.doi.org/10.3389/fnut.2022.948131 Text en Copyright © 2022 Pham, Greppi, Chassard, Braegger and Lacroix. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Pham, Van T.
Greppi, Anna
Chassard, Christophe
Braegger, Christian
Lacroix, Christophe
Stepwise establishment of functional microbial groups in the infant gut between 6 months and 2 years: A prospective cohort study
title Stepwise establishment of functional microbial groups in the infant gut between 6 months and 2 years: A prospective cohort study
title_full Stepwise establishment of functional microbial groups in the infant gut between 6 months and 2 years: A prospective cohort study
title_fullStr Stepwise establishment of functional microbial groups in the infant gut between 6 months and 2 years: A prospective cohort study
title_full_unstemmed Stepwise establishment of functional microbial groups in the infant gut between 6 months and 2 years: A prospective cohort study
title_short Stepwise establishment of functional microbial groups in the infant gut between 6 months and 2 years: A prospective cohort study
title_sort stepwise establishment of functional microbial groups in the infant gut between 6 months and 2 years: a prospective cohort study
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366138/
https://www.ncbi.nlm.nih.gov/pubmed/35967780
http://dx.doi.org/10.3389/fnut.2022.948131
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