Cargando…
Role of hepatic stellate cells in liver ischemia-reperfusion injury
Liver ischemia-reperfusion injury (IRI) is a major complication of liver trauma, resection, and transplantation. IRI may lead to liver dysfunction and failure, but effective approach to address it is still lacking. To better understand the cellular and molecular mechanisms of liver IRI, functional r...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366147/ https://www.ncbi.nlm.nih.gov/pubmed/35967364 http://dx.doi.org/10.3389/fimmu.2022.891868 |
_version_ | 1784765495690395648 |
---|---|
author | Peng, Yuming Yin, Qiang Yuan, Miaoxian Chen, Lijian Shen, Xinyi Xie, Weixin Liu, Jinqiao |
author_facet | Peng, Yuming Yin, Qiang Yuan, Miaoxian Chen, Lijian Shen, Xinyi Xie, Weixin Liu, Jinqiao |
author_sort | Peng, Yuming |
collection | PubMed |
description | Liver ischemia-reperfusion injury (IRI) is a major complication of liver trauma, resection, and transplantation. IRI may lead to liver dysfunction and failure, but effective approach to address it is still lacking. To better understand the cellular and molecular mechanisms of liver IRI, functional roles of numerous cell types, including hepatocytes, Kupffer cells, neutrophils, and sinusoidal endothelial cells, have been intensively studied. In contrast, hepatic stellate cells (HSCs), which are well recognized by their essential functions in facilitating liver protection and repair, have gained less attention in their role in IRI. This review provides a comprehensive summary of the effects of HSCs on the injury stage of liver IRI and their associated molecular mechanisms. In addition, we discuss the regulation of liver repair and regeneration after IRI by HSCs. Finally, we highlight unanswered questions and future avenues of research regarding contributions of HSCs to IRI in the liver. |
format | Online Article Text |
id | pubmed-9366147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93661472022-08-12 Role of hepatic stellate cells in liver ischemia-reperfusion injury Peng, Yuming Yin, Qiang Yuan, Miaoxian Chen, Lijian Shen, Xinyi Xie, Weixin Liu, Jinqiao Front Immunol Immunology Liver ischemia-reperfusion injury (IRI) is a major complication of liver trauma, resection, and transplantation. IRI may lead to liver dysfunction and failure, but effective approach to address it is still lacking. To better understand the cellular and molecular mechanisms of liver IRI, functional roles of numerous cell types, including hepatocytes, Kupffer cells, neutrophils, and sinusoidal endothelial cells, have been intensively studied. In contrast, hepatic stellate cells (HSCs), which are well recognized by their essential functions in facilitating liver protection and repair, have gained less attention in their role in IRI. This review provides a comprehensive summary of the effects of HSCs on the injury stage of liver IRI and their associated molecular mechanisms. In addition, we discuss the regulation of liver repair and regeneration after IRI by HSCs. Finally, we highlight unanswered questions and future avenues of research regarding contributions of HSCs to IRI in the liver. Frontiers Media S.A. 2022-07-28 /pmc/articles/PMC9366147/ /pubmed/35967364 http://dx.doi.org/10.3389/fimmu.2022.891868 Text en Copyright © 2022 Peng, Yin, Yuan, Chen, Shen, Xie and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Peng, Yuming Yin, Qiang Yuan, Miaoxian Chen, Lijian Shen, Xinyi Xie, Weixin Liu, Jinqiao Role of hepatic stellate cells in liver ischemia-reperfusion injury |
title | Role of hepatic stellate cells in liver ischemia-reperfusion injury |
title_full | Role of hepatic stellate cells in liver ischemia-reperfusion injury |
title_fullStr | Role of hepatic stellate cells in liver ischemia-reperfusion injury |
title_full_unstemmed | Role of hepatic stellate cells in liver ischemia-reperfusion injury |
title_short | Role of hepatic stellate cells in liver ischemia-reperfusion injury |
title_sort | role of hepatic stellate cells in liver ischemia-reperfusion injury |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366147/ https://www.ncbi.nlm.nih.gov/pubmed/35967364 http://dx.doi.org/10.3389/fimmu.2022.891868 |
work_keys_str_mv | AT pengyuming roleofhepaticstellatecellsinliverischemiareperfusioninjury AT yinqiang roleofhepaticstellatecellsinliverischemiareperfusioninjury AT yuanmiaoxian roleofhepaticstellatecellsinliverischemiareperfusioninjury AT chenlijian roleofhepaticstellatecellsinliverischemiareperfusioninjury AT shenxinyi roleofhepaticstellatecellsinliverischemiareperfusioninjury AT xieweixin roleofhepaticstellatecellsinliverischemiareperfusioninjury AT liujinqiao roleofhepaticstellatecellsinliverischemiareperfusioninjury |