Disorder in Ca(2+) release unit locations confers robustness but cuts flexibility of heart pacemaking

Excitation–contraction coupling kinetics is dictated by the action potential rate of sinoatrial-nodal cells. These cells generate local Ca releases (LCRs) that activate Na/Ca exchanger current, which accelerates diastolic depolarization and determines the pace. LCRs are generated by clusters of ryan...

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Detalles Bibliográficos
Autores principales: Maltsev, Anna V., Stern, Michael D., Maltsev, Victor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366202/
https://www.ncbi.nlm.nih.gov/pubmed/35943725
http://dx.doi.org/10.1085/jgp.202113061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366202/
https://www.ncbi.nlm.nih.gov/pubmed/35943725
http://dx.doi.org/10.1085/jgp.202113061

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