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Disorder in Ca(2+) release unit locations confers robustness but cuts flexibility of heart pacemaking
Excitation–contraction coupling kinetics is dictated by the action potential rate of sinoatrial-nodal cells. These cells generate local Ca releases (LCRs) that activate Na/Ca exchanger current, which accelerates diastolic depolarization and determines the pace. LCRs are generated by clusters of ryan...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366202/ https://www.ncbi.nlm.nih.gov/pubmed/35943725 http://dx.doi.org/10.1085/jgp.202113061 |