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Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota

Morinda officinalis oligosaccharides (MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan (5-HTP) → ser...

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Detalles Bibliográficos
Autores principales:	Zhang, Zheng-Wei, Gao, Chun-Sheng, Zhang, Heng, Yang, Jian, Wang, Ya-Ping, Pan, Li-Bin, Yu, Hang, He, Chi-Yu, Luo, Hai-Bin, Zhao, Zhen-Xiong, Zhou, Xin-Bo, Wang, Yu-Li, Fu, Jie, Han, Pei, Dong, Yu-Hui, Wang, Gang, Li, Song, Wang, Yan, Jiang, Jian-Dong, Zhong, Wu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366226/ https://www.ncbi.nlm.nih.gov/pubmed/35967282 http://dx.doi.org/10.1016/j.apsb.2022.02.032

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