Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma

Constitutively activated G proteins caused by specific mutations mediate the development of multiple malignancies. The mutated Gαq/11 are perceived as oncogenic drivers in the vast majority of uveal melanoma (UM) cases, making directly targeting Gαq/11 to be a promising strategy for combating UM. He...

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Detalles Bibliográficos
Autores principales: Ge, Yang, Deng, Jun-Jie, Zhu, Jianzheng, Liu, Lu, Ouyang, Shumin, Song, Zhendong, Zhang, Xiaolei, Xiong, Xiao-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366314/
https://www.ncbi.nlm.nih.gov/pubmed/35967274
http://dx.doi.org/10.1016/j.apsb.2022.04.016

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