Cargando…

Randomized Phase II JANUS Study of Atacicept in Patients With IgA Nephropathy and Persistent Proteinuria

INTRODUCTION: Patients with IgA nephropathy (IgAN) and persistent proteinuria are at risk of progression to kidney failure. Atacicept is a novel B-cell–targeted immunomodulator, shown to reduce immunoglobulin levels in patients with autoimmune diseases. METHODS: JANUS (NCT02808429) was a phase II st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barratt, Jonathan, Tumlin, James, Suzuki, Yusuke, Kao, Amy, Aydemir, Aida, Pudota, Kishore, Jin, Hulin, Gühring, Hans, Appel, Gerald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Clinical Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366370/ https://www.ncbi.nlm.nih.gov/pubmed/35967104 http://dx.doi.org/10.1016/j.ekir.2022.05.017

Ejemplares similares

Bortezomib for Reduction of Proteinuria in IgA Nephropathy
por: Hartono, Choli, et al.
Publicado: (2018)

Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission
por: Inagaki, Koji, et al.
Publicado: (2017)

Optimal Proteinuria Target for Renoprotection in Patients with IgA Nephropathy
por: Nam, Ki Heon, et al.
Publicado: (2014)

Tacrolimus decreases proteinuria in patients with refractory IgA nephropathy
por: Hu, Tingyang, et al.
Publicado: (2018)

Hydroxychloroquine Reduces Proteinuria in Indian Patients With IgA Nephropathy
por: Bagchi, Soumita, et al.
Publicado: (2022)

Commentary: Systematic Review of Safety and Efficacy of Atacicept in Treating Immune-Mediated Disorders
por: Isenberg, David A., et al.
Publicado: (2020)

Serum Galactose-Deficient IgA1 Level Is Not Associated with Proteinuria in Children with IgA Nephropathy
por: Hastings, M. Colleen, et al.
Publicado: (2012)

Randomized Phase 2 Trial of Telitacicept in Patients With IgA Nephropathy With Persistent Proteinuria
por: Lv, Jicheng, et al.
Publicado: (2022)

Canagliflozin Markedly Decreased Proteinuria in a Patient With IgA Nephropathy
por: Aameish, Muhammad, et al.
Publicado: (2021)

Primary IgA nephropathy with nephrotic-range proteinuria in Chinese children
por: Zhao, Jing-Li, et al.
Publicado: (2021)

Safety, Tolerability and Efficacy of Narsoplimab, a Novel MASP-2 Inhibitor for the Treatment of IgA Nephropathy
por: Lafayette, Richard A., et al.
Publicado: (2020)

IgA nephropathy: a perspective for 2021
por: Floege, Jürgen, et al.
Publicado: (2021)

Malignant hypertension and nephrotic range proteinuria without hematuria: IgA nephropathy
por: Goswami, R. P., et al.
Publicado: (2013)

Corticosteroid Treatment Influences TA-Proteinuria and Renal Survival in IgA Nephropathy
por: Sarcina, Cristina, et al.
Publicado: (2016)

Severity of foot process effacement is associated with proteinuria in patients with IgA nephropathy
por: Lee, Ji-Hye, et al.
Publicado: (2020)

Effect of SGLT2 inhibitors on the proteinuria reduction in patients with IgA nephropathy
por: Dong, Yaping, et al.
Publicado: (2023)

Attainment of treat-to-target endpoints in SLE patients with high disease activity in the atacicept phase 2b ADDRESS II study
por: Morand, Eric F, et al.
Publicado: (2020)

New insights into the pathogenesis of IgA nephropathy
por: Yeo, See Cheng, et al.
Publicado: (2017)

Comment on: Malignant hypertension and nephrotic range proteinuria without hematuria: IgA nephropathy
por: Nasri, H.
Publicado: (2014)

Significance of tonsillectomy combined with steroid pulse therapy for IgA nephropathy with mild proteinuria
por: Komatsu, Hiroyuki, et al.
Publicado: (2015)

Effects of Hydroxychloroquine on Proteinuria in IgA Nephropathy: A Systematic Review and Meta-Analysis
por: Zhang, Jialing, et al.
Publicado: (2021)

New developments in the genetics, pathogenesis, and therapy of IgA nephropathy
por: Magistroni, Riccardo, et al.
Publicado: (2015)

IgA Nephropathy Genetic Risk Score to Estimate the Prevalence of IgA Nephropathy in UK Biobank
por: Sukcharoen, Kittiya, et al.
Publicado: (2020)

Current understanding of IgA antibodies in the pathogenesis of IgA nephropathy
por: Nihei, Yoshihito, et al.
Publicado: (2023)

New strategies and perspectives on managing IgA nephropathy
por: Selvaskandan, Haresh, et al.
Publicado: (2019)

Prognostic factors of IgA nephropathy presenting with mild proteinuria at the time of diagnosis (a multicenter cohort study)
por: Shirai, Sayuri, et al.
Publicado: (2023)

Integrated safety profile of atacicept: an analysis of pooled data from the atacicept clinical trial programme
por: Gordon, Caroline, et al.
Publicado: (2019)

Author response on: Malignant hypertension and nephrotic range proteinuria without hematuria: IgA nephropathy
por: Goswami, R. P., et al.
Publicado: (2014)

Role of immunosuppressive therapy and predictors of therapeutic effectiveness and renal outcome in IgA nephropathy with proteinuria
por: Ruan, Yiping, et al.
Publicado: (2015)

Corticosteroids or immunosuppressants were not superior to supportive care in IgA nephropathy patients with mild proteinuria
por: Pei, Gaiqin, et al.
Publicado: (2020)

Challenges in IgA Nephropathy Management: An Era of Complement Inhibition
por: Tesař, Vladimir, et al.
Publicado: (2023)

Effect of Immunosuppressive Drugs on the Changes of Serum Galactose-Deficient IgA1 in Patients with IgA Nephropathy
por: Kim, Min Jeong, et al.
Publicado: (2016)

Why Target the Gut to Treat IgA Nephropathy?
por: Barratt, Jonathan, et al.
Publicado: (2020)

The Role of IgA in the Pathogenesis of IgA Nephropathy
por: Perše, Martina, et al.
Publicado: (2019)

Immunosuppressive agents versus steroids in the treatment of IgA nephropathy-induced proteinuria: A meta-analysis
por: Liu, Yanli, et al.
Publicado: (2016)

Proteinuria during Follow-Up Period and Long-Term Renal Survival of Childhood IgA Nephropathy
por: Kamei, Koichi, et al.
Publicado: (2016)

Long-term prognosis of IgA nephropathy presenting with minimal or no proteinuria: A single center experience
por: Imai, N., et al.
Publicado: (2016)

Immunosuppressive agents versus steroids in the treatment of IgA nephropathy-induced proteinuria: A meta-analysis
por: Liu, Yanli, et al.
Publicado: (2019)

Comparison of the effects of hydroxychloroquine and corticosteroid treatment on proteinuria in IgA nephropathy: a case-control study
por: Yang, Ya-zi, et al.
Publicado: (2019)

In Acute IgA Nephropathy, Proteinuria and Creatinine Are in the Spot, but Podocyturia Operates in Silence: Any Place for Amiloride?
por: Trimarchi, H., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_a80n88n3vnm3jokegev4us1uvf