Cargando…

Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study

BACKGROUND: The increased risk of fracture has been associated with weight loss in patients with diabetes or chronic kidney disease. However, the relationship between weight changes over time and fracture risk in patients with diabetic kidney disease is still unknown. METHODS: A total number of 78,9...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Chang Seong, Choi, Hong Sang, Bae, Eun Hui, Ma, Seong Kwon, Kim, Bongseong, Han, Kyung-Do, Kim, Soo Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366468/
https://www.ncbi.nlm.nih.gov/pubmed/35966851
http://dx.doi.org/10.3389/fmed.2022.912152
_version_ 1784765572192403456
author Kim, Chang Seong
Choi, Hong Sang
Bae, Eun Hui
Ma, Seong Kwon
Kim, Bongseong
Han, Kyung-Do
Kim, Soo Wan
author_facet Kim, Chang Seong
Choi, Hong Sang
Bae, Eun Hui
Ma, Seong Kwon
Kim, Bongseong
Han, Kyung-Do
Kim, Soo Wan
author_sort Kim, Chang Seong
collection PubMed
description BACKGROUND: The increased risk of fracture has been associated with weight loss in patients with diabetes or chronic kidney disease. However, the relationship between weight changes over time and fracture risk in patients with diabetic kidney disease is still unknown. METHODS: A total number of 78,922 patients with diabetic kidney disease, aged ≥ 40 years, were selected using the Korean National Health Insurance Service database, between 2009 and 2012. They were followed up until the end of 2018. Weight change was defined as the difference in body weight from the index year to 2 years later. Weight changes were then divided into five categories, ranging from weight loss of ≥10% to weight gain of ≥10%. RESULTS: Fractures were identified in 9,847 patients with diabetic kidney disease, over a median follow-up of 5.2 years. The risk of composite fracture of the vertebral, hip, or other sites increased as the weight change increased. Specifically, patients with ≥10% weight loss (hazard ratio [HR], 1.286; 95% confidence interval [CI], 1.184–1.398) and ≥10% weight gain (HR, 1.198; 95% CI, 1.080–1.330) showed a higher HR compared to those with ≤ 5% weight change after adjusting for several confounding factors. Higher HR of vertebral and hip fractures was also seen with increased weight loss or gain. In particular, patients with ≥10% weight loss showed the highest HR for hip fractures (HR, 1.738; 95% CI, 1.489–2.028). CONCLUSIONS: Both weight loss and weight gain increase the risk of fracture in patients with diabetic kidney disease. Therefore, patients with diabetic kidney disease who experience weight changes should be made aware of the risk of fracture.
format Online
Article
Text
id pubmed-9366468
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93664682022-08-12 Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study Kim, Chang Seong Choi, Hong Sang Bae, Eun Hui Ma, Seong Kwon Kim, Bongseong Han, Kyung-Do Kim, Soo Wan Front Med (Lausanne) Medicine BACKGROUND: The increased risk of fracture has been associated with weight loss in patients with diabetes or chronic kidney disease. However, the relationship between weight changes over time and fracture risk in patients with diabetic kidney disease is still unknown. METHODS: A total number of 78,922 patients with diabetic kidney disease, aged ≥ 40 years, were selected using the Korean National Health Insurance Service database, between 2009 and 2012. They were followed up until the end of 2018. Weight change was defined as the difference in body weight from the index year to 2 years later. Weight changes were then divided into five categories, ranging from weight loss of ≥10% to weight gain of ≥10%. RESULTS: Fractures were identified in 9,847 patients with diabetic kidney disease, over a median follow-up of 5.2 years. The risk of composite fracture of the vertebral, hip, or other sites increased as the weight change increased. Specifically, patients with ≥10% weight loss (hazard ratio [HR], 1.286; 95% confidence interval [CI], 1.184–1.398) and ≥10% weight gain (HR, 1.198; 95% CI, 1.080–1.330) showed a higher HR compared to those with ≤ 5% weight change after adjusting for several confounding factors. Higher HR of vertebral and hip fractures was also seen with increased weight loss or gain. In particular, patients with ≥10% weight loss showed the highest HR for hip fractures (HR, 1.738; 95% CI, 1.489–2.028). CONCLUSIONS: Both weight loss and weight gain increase the risk of fracture in patients with diabetic kidney disease. Therefore, patients with diabetic kidney disease who experience weight changes should be made aware of the risk of fracture. Frontiers Media S.A. 2022-07-28 /pmc/articles/PMC9366468/ /pubmed/35966851 http://dx.doi.org/10.3389/fmed.2022.912152 Text en Copyright © 2022 Kim, Choi, Bae, Ma, Kim, Han and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Kim, Chang Seong
Choi, Hong Sang
Bae, Eun Hui
Ma, Seong Kwon
Kim, Bongseong
Han, Kyung-Do
Kim, Soo Wan
Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study
title Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study
title_full Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study
title_fullStr Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study
title_full_unstemmed Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study
title_short Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study
title_sort weight change and fracture risk in patients with diabetic kidney disease: a nationwide population-based study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366468/
https://www.ncbi.nlm.nih.gov/pubmed/35966851
http://dx.doi.org/10.3389/fmed.2022.912152
work_keys_str_mv AT kimchangseong weightchangeandfractureriskinpatientswithdiabetickidneydiseaseanationwidepopulationbasedstudy
AT choihongsang weightchangeandfractureriskinpatientswithdiabetickidneydiseaseanationwidepopulationbasedstudy
AT baeeunhui weightchangeandfractureriskinpatientswithdiabetickidneydiseaseanationwidepopulationbasedstudy
AT maseongkwon weightchangeandfractureriskinpatientswithdiabetickidneydiseaseanationwidepopulationbasedstudy
AT kimbongseong weightchangeandfractureriskinpatientswithdiabetickidneydiseaseanationwidepopulationbasedstudy
AT hankyungdo weightchangeandfractureriskinpatientswithdiabetickidneydiseaseanationwidepopulationbasedstudy
AT kimsoowan weightchangeandfractureriskinpatientswithdiabetickidneydiseaseanationwidepopulationbasedstudy