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Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study
BACKGROUND: The increased risk of fracture has been associated with weight loss in patients with diabetes or chronic kidney disease. However, the relationship between weight changes over time and fracture risk in patients with diabetic kidney disease is still unknown. METHODS: A total number of 78,9...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366468/ https://www.ncbi.nlm.nih.gov/pubmed/35966851 http://dx.doi.org/10.3389/fmed.2022.912152 |
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author | Kim, Chang Seong Choi, Hong Sang Bae, Eun Hui Ma, Seong Kwon Kim, Bongseong Han, Kyung-Do Kim, Soo Wan |
author_facet | Kim, Chang Seong Choi, Hong Sang Bae, Eun Hui Ma, Seong Kwon Kim, Bongseong Han, Kyung-Do Kim, Soo Wan |
author_sort | Kim, Chang Seong |
collection | PubMed |
description | BACKGROUND: The increased risk of fracture has been associated with weight loss in patients with diabetes or chronic kidney disease. However, the relationship between weight changes over time and fracture risk in patients with diabetic kidney disease is still unknown. METHODS: A total number of 78,922 patients with diabetic kidney disease, aged ≥ 40 years, were selected using the Korean National Health Insurance Service database, between 2009 and 2012. They were followed up until the end of 2018. Weight change was defined as the difference in body weight from the index year to 2 years later. Weight changes were then divided into five categories, ranging from weight loss of ≥10% to weight gain of ≥10%. RESULTS: Fractures were identified in 9,847 patients with diabetic kidney disease, over a median follow-up of 5.2 years. The risk of composite fracture of the vertebral, hip, or other sites increased as the weight change increased. Specifically, patients with ≥10% weight loss (hazard ratio [HR], 1.286; 95% confidence interval [CI], 1.184–1.398) and ≥10% weight gain (HR, 1.198; 95% CI, 1.080–1.330) showed a higher HR compared to those with ≤ 5% weight change after adjusting for several confounding factors. Higher HR of vertebral and hip fractures was also seen with increased weight loss or gain. In particular, patients with ≥10% weight loss showed the highest HR for hip fractures (HR, 1.738; 95% CI, 1.489–2.028). CONCLUSIONS: Both weight loss and weight gain increase the risk of fracture in patients with diabetic kidney disease. Therefore, patients with diabetic kidney disease who experience weight changes should be made aware of the risk of fracture. |
format | Online Article Text |
id | pubmed-9366468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93664682022-08-12 Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study Kim, Chang Seong Choi, Hong Sang Bae, Eun Hui Ma, Seong Kwon Kim, Bongseong Han, Kyung-Do Kim, Soo Wan Front Med (Lausanne) Medicine BACKGROUND: The increased risk of fracture has been associated with weight loss in patients with diabetes or chronic kidney disease. However, the relationship between weight changes over time and fracture risk in patients with diabetic kidney disease is still unknown. METHODS: A total number of 78,922 patients with diabetic kidney disease, aged ≥ 40 years, were selected using the Korean National Health Insurance Service database, between 2009 and 2012. They were followed up until the end of 2018. Weight change was defined as the difference in body weight from the index year to 2 years later. Weight changes were then divided into five categories, ranging from weight loss of ≥10% to weight gain of ≥10%. RESULTS: Fractures were identified in 9,847 patients with diabetic kidney disease, over a median follow-up of 5.2 years. The risk of composite fracture of the vertebral, hip, or other sites increased as the weight change increased. Specifically, patients with ≥10% weight loss (hazard ratio [HR], 1.286; 95% confidence interval [CI], 1.184–1.398) and ≥10% weight gain (HR, 1.198; 95% CI, 1.080–1.330) showed a higher HR compared to those with ≤ 5% weight change after adjusting for several confounding factors. Higher HR of vertebral and hip fractures was also seen with increased weight loss or gain. In particular, patients with ≥10% weight loss showed the highest HR for hip fractures (HR, 1.738; 95% CI, 1.489–2.028). CONCLUSIONS: Both weight loss and weight gain increase the risk of fracture in patients with diabetic kidney disease. Therefore, patients with diabetic kidney disease who experience weight changes should be made aware of the risk of fracture. Frontiers Media S.A. 2022-07-28 /pmc/articles/PMC9366468/ /pubmed/35966851 http://dx.doi.org/10.3389/fmed.2022.912152 Text en Copyright © 2022 Kim, Choi, Bae, Ma, Kim, Han and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Kim, Chang Seong Choi, Hong Sang Bae, Eun Hui Ma, Seong Kwon Kim, Bongseong Han, Kyung-Do Kim, Soo Wan Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study |
title | Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study |
title_full | Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study |
title_fullStr | Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study |
title_full_unstemmed | Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study |
title_short | Weight change and fracture risk in patients with diabetic kidney disease: A nationwide population-based study |
title_sort | weight change and fracture risk in patients with diabetic kidney disease: a nationwide population-based study |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366468/ https://www.ncbi.nlm.nih.gov/pubmed/35966851 http://dx.doi.org/10.3389/fmed.2022.912152 |
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