Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus

Severe fever with thrombocytopenia syndrome (SFTS), which is caused by SFTS virus (SFTSV), poses a serious threat to global public health, with high fatalities and an increasing prevalence. As effective therapies and prevention strategies are limited, there is an urgent need to elucidate the pathoge...

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Autores principales: Wang, Tong, Xu, Ling, Zhu, Bin, Wang, Junzhong, Zheng, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366518/
https://www.ncbi.nlm.nih.gov/pubmed/35967309
http://dx.doi.org/10.3389/fimmu.2022.937684
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author Wang, Tong
Xu, Ling
Zhu, Bin
Wang, Junzhong
Zheng, Xin
author_facet Wang, Tong
Xu, Ling
Zhu, Bin
Wang, Junzhong
Zheng, Xin
author_sort Wang, Tong
collection PubMed
description Severe fever with thrombocytopenia syndrome (SFTS), which is caused by SFTS virus (SFTSV), poses a serious threat to global public health, with high fatalities and an increasing prevalence. As effective therapies and prevention strategies are limited, there is an urgent need to elucidate the pathogenesis of SFTS. SFTSV has evolved several mechanisms to escape from host immunity. In this review, we summarize the mechanisms through which SFTSV escapes host immune responses, including the inhibition of innate immunity and evasion of adaptive immunity. Understanding the pathogenesis of SFTS will aid in the development of new strategies for the treatment of this disease.
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spelling pubmed-93665182022-08-12 Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus Wang, Tong Xu, Ling Zhu, Bin Wang, Junzhong Zheng, Xin Front Immunol Immunology Severe fever with thrombocytopenia syndrome (SFTS), which is caused by SFTS virus (SFTSV), poses a serious threat to global public health, with high fatalities and an increasing prevalence. As effective therapies and prevention strategies are limited, there is an urgent need to elucidate the pathogenesis of SFTS. SFTSV has evolved several mechanisms to escape from host immunity. In this review, we summarize the mechanisms through which SFTSV escapes host immune responses, including the inhibition of innate immunity and evasion of adaptive immunity. Understanding the pathogenesis of SFTS will aid in the development of new strategies for the treatment of this disease. Frontiers Media S.A. 2022-07-28 /pmc/articles/PMC9366518/ /pubmed/35967309 http://dx.doi.org/10.3389/fimmu.2022.937684 Text en Copyright © 2022 Wang, Xu, Zhu, Wang and Zheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Tong
Xu, Ling
Zhu, Bin
Wang, Junzhong
Zheng, Xin
Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus
title Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus
title_full Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus
title_fullStr Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus
title_full_unstemmed Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus
title_short Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus
title_sort immune escape mechanisms of severe fever with thrombocytopenia syndrome virus
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366518/
https://www.ncbi.nlm.nih.gov/pubmed/35967309
http://dx.doi.org/10.3389/fimmu.2022.937684
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