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Diclofenac derivatives as concomitant inhibitors of cholinesterase, monoamine oxidase, cyclooxygenase-2 and 5-lipoxygenase for the treatment of Alzheimer's disease: synthesis, pharmacology, toxicity and docking studies

Targeting concomitantly cholinesterase (ChEs) and monoamine oxidases (MAO-A and MAO-B) is a key strategy to treat multifactorial Alzheimer's disease (AD). Moreover, it is reported that the expression of cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) is increased significantly in the brain of A...

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Detalles Bibliográficos
Autores principales:	Javed, Muhammad Aamir, Bibi, Saba, Jan, Muhammad Saeed, Ikram, Muhammad, Zaidi, Asma, Farooq, Umar, Sadiq, Abdul, Rashid, Umer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366597/ https://www.ncbi.nlm.nih.gov/pubmed/36105972 http://dx.doi.org/10.1039/d2ra04183a

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