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New Triterpenoids from the Fruiting Bodies of Laetiporus sulphureus and Their Anti-Inflammatory Activity
[Image: see text] Laetiporus sulphureus is a popular medicinal mushroom with diverse pharmacological activities in many Asian countries. Four new triterpenoids, named sulphurenoids A–D (1–4), along with 12 known analogues, were isolated from the fruits of L. sulphureus. Nuclear magnetic resonance, i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366770/ https://www.ncbi.nlm.nih.gov/pubmed/35967012 http://dx.doi.org/10.1021/acsomega.2c02165 |
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author | Khalilov, Qosimjon Numonov, Sodik Sukhrobov, Parviz Bobakulov, Khayrulla Sharopov, Farukh Habasi, Madina Zhao, Jiangyu Yuan, Tao Aisa, Haji Akber |
author_facet | Khalilov, Qosimjon Numonov, Sodik Sukhrobov, Parviz Bobakulov, Khayrulla Sharopov, Farukh Habasi, Madina Zhao, Jiangyu Yuan, Tao Aisa, Haji Akber |
author_sort | Khalilov, Qosimjon |
collection | PubMed |
description | [Image: see text] Laetiporus sulphureus is a popular medicinal mushroom with diverse pharmacological activities in many Asian countries. Four new triterpenoids, named sulphurenoids A–D (1–4), along with 12 known analogues, were isolated from the fruits of L. sulphureus. Nuclear magnetic resonance, infrared spectroscopy, and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) techniques were used for the investigation of the chemical structure of isolated compounds. In addition, the anti-inflammatory activity of three new compounds (2–4) was tested for NO production in lipopolysaccharide-induced RAW 264.7 cells. The IC(50) values of isolated triterpenoids ranged from 14.3 to 42.3 μM, which were more effective than the positive control (IC(50) for minocycline was 73.0 μM). The experimentally obtained anti-inflammatory activity data of L. sulphureus are in agreement with its traditional use. |
format | Online Article Text |
id | pubmed-9366770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-93667702022-08-12 New Triterpenoids from the Fruiting Bodies of Laetiporus sulphureus and Their Anti-Inflammatory Activity Khalilov, Qosimjon Numonov, Sodik Sukhrobov, Parviz Bobakulov, Khayrulla Sharopov, Farukh Habasi, Madina Zhao, Jiangyu Yuan, Tao Aisa, Haji Akber ACS Omega [Image: see text] Laetiporus sulphureus is a popular medicinal mushroom with diverse pharmacological activities in many Asian countries. Four new triterpenoids, named sulphurenoids A–D (1–4), along with 12 known analogues, were isolated from the fruits of L. sulphureus. Nuclear magnetic resonance, infrared spectroscopy, and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) techniques were used for the investigation of the chemical structure of isolated compounds. In addition, the anti-inflammatory activity of three new compounds (2–4) was tested for NO production in lipopolysaccharide-induced RAW 264.7 cells. The IC(50) values of isolated triterpenoids ranged from 14.3 to 42.3 μM, which were more effective than the positive control (IC(50) for minocycline was 73.0 μM). The experimentally obtained anti-inflammatory activity data of L. sulphureus are in agreement with its traditional use. American Chemical Society 2022-07-27 /pmc/articles/PMC9366770/ /pubmed/35967012 http://dx.doi.org/10.1021/acsomega.2c02165 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Khalilov, Qosimjon Numonov, Sodik Sukhrobov, Parviz Bobakulov, Khayrulla Sharopov, Farukh Habasi, Madina Zhao, Jiangyu Yuan, Tao Aisa, Haji Akber New Triterpenoids from the Fruiting Bodies of Laetiporus sulphureus and Their Anti-Inflammatory Activity |
title | New Triterpenoids
from the Fruiting Bodies of Laetiporus sulphureus and Their Anti-Inflammatory Activity |
title_full | New Triterpenoids
from the Fruiting Bodies of Laetiporus sulphureus and Their Anti-Inflammatory Activity |
title_fullStr | New Triterpenoids
from the Fruiting Bodies of Laetiporus sulphureus and Their Anti-Inflammatory Activity |
title_full_unstemmed | New Triterpenoids
from the Fruiting Bodies of Laetiporus sulphureus and Their Anti-Inflammatory Activity |
title_short | New Triterpenoids
from the Fruiting Bodies of Laetiporus sulphureus and Their Anti-Inflammatory Activity |
title_sort | new triterpenoids
from the fruiting bodies of laetiporus sulphureus and their anti-inflammatory activity |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366770/ https://www.ncbi.nlm.nih.gov/pubmed/35967012 http://dx.doi.org/10.1021/acsomega.2c02165 |
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