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Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes
BACKGROUND: Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of type 1 diabetes mellitus (T1DM) that has increased during the COVID-19 pandemic. This study will not only shed light on such life-threatening complications but also be a step to increase the awareness of health...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366798/ https://www.ncbi.nlm.nih.gov/pubmed/35953513 http://dx.doi.org/10.1038/s41390-022-02241-2 |
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author | Elgenidy, Anas Awad, Ahmed K. Saad, Khaled Atef, Mostafa El-Leithy, Hatem Helmy Obiedallah, Ahmed A. Hammad, Emad M. Ahmad, Faisal-Alkhateeb Ali, Ahmad M. Dailah, Hamad Ghaleb Elhoufey, Amira Taha, Samaher Fathy |
author_facet | Elgenidy, Anas Awad, Ahmed K. Saad, Khaled Atef, Mostafa El-Leithy, Hatem Helmy Obiedallah, Ahmed A. Hammad, Emad M. Ahmad, Faisal-Alkhateeb Ali, Ahmad M. Dailah, Hamad Ghaleb Elhoufey, Amira Taha, Samaher Fathy |
author_sort | Elgenidy, Anas |
collection | PubMed |
description | BACKGROUND: Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of type 1 diabetes mellitus (T1DM) that has increased during the COVID-19 pandemic. This study will not only shed light on such life-threatening complications but also be a step to increase the awareness of healthcare providers about such complications in the upcoming pandemic waves and increased dependence on telemedicine. Thus, we aimed to further investigate the increase of DKA in pediatrics. METHODS: PubMed, Web of Science, and Scopus were broadly searched for studies assessing the incidence of DKA in pediatrics during the COVID-19 pandemic. RESULTS: Our study included 24 papers with a total of 124,597 children with diabetes. A statistically significant increase occurred in the risk of DKA among newly diagnosed T1DM patients during the pandemic (RR 1.41; 95% CI 1.19, 1.67; p < 0.01; I(2) = 86%), especially in the severe form of DKA (RR 1.66: 95% CI 1.3, 2.11) when compared to before. CONCLUSION: DKA in newly diagnosed children with T1DM has increased during the pandemic and presented with a severe form. This may reflect that COVID-19 may have contributed not only to the development but also the severity of DKA. IMPACT: Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes mellitus (T1DM) that has increased during the COVID-19 pandemic. Our study included 25 papers with a total of 124,597 children with diabetes. A statistically significant increase occurred in the risk of DKA among newly diagnosed T1DM patients during the pandemic. Our findings reflect that COVID-19 may have an altered presentation in T1DM and can be related to DKA severity. |
format | Online Article Text |
id | pubmed-9366798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-93667982022-08-11 Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes Elgenidy, Anas Awad, Ahmed K. Saad, Khaled Atef, Mostafa El-Leithy, Hatem Helmy Obiedallah, Ahmed A. Hammad, Emad M. Ahmad, Faisal-Alkhateeb Ali, Ahmad M. Dailah, Hamad Ghaleb Elhoufey, Amira Taha, Samaher Fathy Pediatr Res Systematic Review BACKGROUND: Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of type 1 diabetes mellitus (T1DM) that has increased during the COVID-19 pandemic. This study will not only shed light on such life-threatening complications but also be a step to increase the awareness of healthcare providers about such complications in the upcoming pandemic waves and increased dependence on telemedicine. Thus, we aimed to further investigate the increase of DKA in pediatrics. METHODS: PubMed, Web of Science, and Scopus were broadly searched for studies assessing the incidence of DKA in pediatrics during the COVID-19 pandemic. RESULTS: Our study included 24 papers with a total of 124,597 children with diabetes. A statistically significant increase occurred in the risk of DKA among newly diagnosed T1DM patients during the pandemic (RR 1.41; 95% CI 1.19, 1.67; p < 0.01; I(2) = 86%), especially in the severe form of DKA (RR 1.66: 95% CI 1.3, 2.11) when compared to before. CONCLUSION: DKA in newly diagnosed children with T1DM has increased during the pandemic and presented with a severe form. This may reflect that COVID-19 may have contributed not only to the development but also the severity of DKA. IMPACT: Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes mellitus (T1DM) that has increased during the COVID-19 pandemic. Our study included 25 papers with a total of 124,597 children with diabetes. A statistically significant increase occurred in the risk of DKA among newly diagnosed T1DM patients during the pandemic. Our findings reflect that COVID-19 may have an altered presentation in T1DM and can be related to DKA severity. Nature Publishing Group US 2022-08-11 2023 /pmc/articles/PMC9366798/ /pubmed/35953513 http://dx.doi.org/10.1038/s41390-022-02241-2 Text en © The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Systematic Review Elgenidy, Anas Awad, Ahmed K. Saad, Khaled Atef, Mostafa El-Leithy, Hatem Helmy Obiedallah, Ahmed A. Hammad, Emad M. Ahmad, Faisal-Alkhateeb Ali, Ahmad M. Dailah, Hamad Ghaleb Elhoufey, Amira Taha, Samaher Fathy Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes |
title | Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes |
title_full | Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes |
title_fullStr | Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes |
title_full_unstemmed | Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes |
title_short | Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes |
title_sort | incidence of diabetic ketoacidosis during covid-19 pandemic: a meta-analysis of 124,597 children with diabetes |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366798/ https://www.ncbi.nlm.nih.gov/pubmed/35953513 http://dx.doi.org/10.1038/s41390-022-02241-2 |
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