Advances in Noble-Metal Nanoparticle-Based Fluorescence Detection of Organophosphorus Chemical Warfare Agents

[Image: see text] Efficient and simple detection of chemical warfare agents (CWAs) is an essential step in minimizing the potentially lethal consequences of chemical weapons. CWAs are a family of organic chemicals that are used as chemical weapons because of their enormous severity and lethal effects when faced with unforeseen challenges. To stop the spread of CWAs, it is critical to develop a platform that detects them in a sensitive, timely, selective, and minimally invasive manner. Rapid advances in the demand for on-site sensors, metal nanoparticles, and biomarker identification for CWAs have made it possible to use fluorescence as a precise real-time and point-of-care (POCT) testing technique. For POCT-based applications, the new capabilities of micro- and nanomotors offer enormous prospects. In recent decades, significant progress has been made in the design of fluorescent sensors and the further development of noble metal nanoparticles for the detection of organophosphorus CWAs, as described in this review. Through this work, recent attempts to fabricate sensors that can detect organophosphorus CWAs through changes in their fluorescence properties have been summarized. Finally, an integrated outlook on how noble metal nanoparticles could be used to develop smart sensors for organophosphorus CWAs that communicate with and control electronic devices to monitor and improve the health of individuals.