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From strain engineering to process development: monoclonal antibody production with an unnatural amino acid in Pichia pastoris
BACKGROUND: Expansion of the genetic code is a frequently employed approach for the modification of recombinant protein properties. It involves reassignment of a codon to another, e.g., unnatural, amino acid and requires the action of a pair of orthogonal tRNA and aminoacyl tRNA synthetase modified...
Autores principales: | Tir, Nora, Heistinger, Lina, Grünwald-Gruber, Clemens, Jakob, Leo A., Dickgiesser, Stephan, Rasche, Nicolas, Mattanovich, Diethard |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367057/ https://www.ncbi.nlm.nih.gov/pubmed/35953849 http://dx.doi.org/10.1186/s12934-022-01882-6 |
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