Sequential acid/reduction response of triblock copolymeric nanomicelles to release camptothecin and toll-like receptor 7/8 agonist for orchestrated chemoimmunotherapy

BACKGROUND: Immunosuppressive tumor immune microenvironment (TIME) lowers immunotherapy effectiveness. Additionally, low penetration efficiency and unpredictable drug release in tumor areas restrict tumor therapy. METHODS: A triblock copolymeric micelle (Nano(PCPT+PIMDQ)) was developed to carry the...

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Detalles Bibliográficos
Autores principales: Ge, Xiaoyan, Hao, Yanyun, Li, Hui, Zhao, Huajun, Liu, Yang, Liu, Yutong, Li, Xia, Chen, Hongfei, Zou, Jing, Zhang, Shiying, Huang, Lingling, Shan, Gang, Zhang, Zhiyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367092/
https://www.ncbi.nlm.nih.gov/pubmed/35953798
http://dx.doi.org/10.1186/s12951-022-01577-5

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