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In silico-guided metabolic engineering of Bacillus subtilis for efficient biosynthesis of purine nucleosides by blocking the key backflow nodes

BACKGROUND: Purine nucleosides play essential roles in cellular physiological processes and have a wide range of applications in the fields of antitumor/antiviral drugs and food. However, microbial overproduction of purine nucleosides by de novo metabolic engineering remains a great challenge due to...

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Detalles Bibliográficos
Autores principales:	Deng, Aihua, Qiu, Qidi, Sun, Qinyun, Chen, Zhenxiang, Wang, Junyue, Zhang, Yu, Liu, Shuwen, Wen, Tingyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367096/ https://www.ncbi.nlm.nih.gov/pubmed/35953809 http://dx.doi.org/10.1186/s13068-022-02179-x

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