The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease

Diabetic kidney disease (DKD) causes the greatest proportion of end-stage renal disease (ESRD)–related mortality and has become a high concern in patients with diabetes mellitus (DM). Bone is considered an endocrine organ, playing an emerging role in regulating glucose and energy metabolism. Accumul...

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Autores principales: Li, Yixuan, Gu, Zuhua, Wang, Jun, Wang, Yangang, Chen, Xian, Dong, Bingzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367194/
https://www.ncbi.nlm.nih.gov/pubmed/35966090
http://dx.doi.org/10.3389/fendo.2022.938830
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author Li, Yixuan
Gu, Zuhua
Wang, Jun
Wang, Yangang
Chen, Xian
Dong, Bingzi
author_facet Li, Yixuan
Gu, Zuhua
Wang, Jun
Wang, Yangang
Chen, Xian
Dong, Bingzi
author_sort Li, Yixuan
collection PubMed
description Diabetic kidney disease (DKD) causes the greatest proportion of end-stage renal disease (ESRD)–related mortality and has become a high concern in patients with diabetes mellitus (DM). Bone is considered an endocrine organ, playing an emerging role in regulating glucose and energy metabolism. Accumulating research has proven that bone-derived hormones are involved in glucose metabolism and the pathogenesis of DM complications, especially DKD. Furthermore, these hormones are considered to be promising predictors and prospective treatment targets for DM and DKD. In this review, we focused on bone-derived hormones, including fibroblast growth factor 23, osteocalcin, sclerostin, and lipocalin 2, and summarized their role in regulating glucose metabolism and DKD.
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spelling pubmed-93671942022-08-12 The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease Li, Yixuan Gu, Zuhua Wang, Jun Wang, Yangang Chen, Xian Dong, Bingzi Front Endocrinol (Lausanne) Endocrinology Diabetic kidney disease (DKD) causes the greatest proportion of end-stage renal disease (ESRD)–related mortality and has become a high concern in patients with diabetes mellitus (DM). Bone is considered an endocrine organ, playing an emerging role in regulating glucose and energy metabolism. Accumulating research has proven that bone-derived hormones are involved in glucose metabolism and the pathogenesis of DM complications, especially DKD. Furthermore, these hormones are considered to be promising predictors and prospective treatment targets for DM and DKD. In this review, we focused on bone-derived hormones, including fibroblast growth factor 23, osteocalcin, sclerostin, and lipocalin 2, and summarized their role in regulating glucose metabolism and DKD. Frontiers Media S.A. 2022-07-11 /pmc/articles/PMC9367194/ /pubmed/35966090 http://dx.doi.org/10.3389/fendo.2022.938830 Text en Copyright © 2022 Li, Gu, Wang, Wang, Chen and Dong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Li, Yixuan
Gu, Zuhua
Wang, Jun
Wang, Yangang
Chen, Xian
Dong, Bingzi
The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease
title The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease
title_full The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease
title_fullStr The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease
title_full_unstemmed The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease
title_short The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease
title_sort emerging role of bone-derived hormones in diabetes mellitus and diabetic kidney disease
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367194/
https://www.ncbi.nlm.nih.gov/pubmed/35966090
http://dx.doi.org/10.3389/fendo.2022.938830
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