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Assessment of Strategies for Safe Drug Discontinuation and Transition of Denosumab Treatment in PMO—Insights From a Mechanistic PK/PD Model of Bone Turnover

Denosumab (Dmab) treatment against postmenopausal osteoporosis (PMO) has proven very efficient in increasing bone mineral density (BMD) and reducing the risk of bone fractures. However, concerns have been recently raised regarding safety when drug treatment is discontinued. Mechanistic pharmacokinet...

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Detalles Bibliográficos
Autores principales:	Martínez-Reina, Javier, Calvo-Gallego, José Luis, Martin, Madge, Pivonka, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367195/ https://www.ncbi.nlm.nih.gov/pubmed/35966026 http://dx.doi.org/10.3389/fbioe.2022.886579

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