Pharmacologic Targeting of MMP2/9 Decreases Peritoneal Metastasis Formation of Colorectal Cancer in a Human Ex Vivo Peritoneum Culture Model

SIMPLE SUMMARY: We investigated the effects of matrix metalloproteinases (MMPs) on the peritoneal attachment of colorectal cancer cells in patient samples and in a human ex vivo peritoneum model. MMP2/9 overexpression and enhanced fibronectin cleavage occurred during peritoneal colonisation, which c...

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Detalles Bibliográficos
Autores principales: Koch, Jana, Mönch, Dina, Maaß, Annika, Mangold, Alina, Gužvić, Miodrag, Mürdter, Thomas, Leibold, Tobias, Dahlke, Marc-H., Renner, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367441/
https://www.ncbi.nlm.nih.gov/pubmed/35954423
http://dx.doi.org/10.3390/cancers14153760

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