Cargando…

Germline Variants Associated with Nasopharyngeal Carcinoma Predisposition Identified through Whole-Exome Sequencing

SIMPLE SUMMARY: The aim of this study was to identify the germline genetic variants associated with an increased risk of developing nasopharyngeal carcinoma (NPC). DNA samples from 119 Singaporean NPC patients were sequenced, with 17 pathogenic variants in 17 genes found to be enriched in NPC patien...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Ning-Yuan, Hum, Melissa, Ong, Pei-Yi, Myint, Matthew Khine, Ong, Enya H. W., Low, Kar-Perng, Li, Zheng, Goh, Boon-Cher, Tay, Joshua K., Loh, Kwok-Seng, Chua, Melvin L. K., Lee, Soo-Chin, Khor, Chiea-Chuen, Lee, Ann S. G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367457/ https://www.ncbi.nlm.nih.gov/pubmed/35954343 http://dx.doi.org/10.3390/cancers14153680

Ejemplares similares

Whole-exome sequencing of BRCA-negative breast cancer patients and case–control analyses identify variants associated with breast cancer susceptibility
por: Lee, Ning Yuan, et al.
Publicado: (2022)

Correction: Whole-exome sequencing of BRCA-negative breast cancer patients and case–control analyses identify variants associated with breast cancer susceptibility
por: Lee, Ning Yuan, et al.
Publicado: (2022)

Germline Polymorphisms and Length of Survival of Nasopharyngeal Carcinoma: An Exome‐Wide Association Study in Multiple Cohorts
por: Guo, Yun‐Miao, et al.
Publicado: (2020)

Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole-exome sequencing
por: Vogelaar, Ingrid P, et al.
Publicado: (2017)

Germline predisposition to genitourinary rhabdomyosarcoma
por: Schneider, Kami Wolfe, et al.
Publicado: (2020)

Development and validation of a nomogram (APGRC) to predict the presence of germline DNA damage repair pathogenic variants in Asian patients with prostate cancer
por: Zhang, Tingwei, et al.
Publicado: (2023)

Germline and Somatic Whole-Exome Sequencing Identifies New Candidate Genes Involved in Familial Predisposition to Serrated Polyposis Syndrome
por: Soares de Lima, Yasmin, et al.
Publicado: (2021)

Whole exome sequencing identifies recessive germline mutations in FAM160A1 in familial NK/T cell lymphoma
por: Chan, Jason Yongsheng, et al.
Publicado: (2018)

Molecular Pathogenesis in Myeloid Neoplasms with Germline Predisposition
por: Gao, Juehua, et al.
Publicado: (2021)

Germline Structural Variations in Cancer Predisposition Genes
por: Pócza, Tímea, et al.
Publicado: (2021)

Diabetes predisposition inherited through maternal germline
por: Zhu, Hong, et al.
Publicado: (2022)

Recurrent somatic mutations and low germline predisposition mutations in Korean ALL patients
por: Shin, Sang-Yong, et al.
Publicado: (2021)

Identification of a Novel Candidate Gene for Serrated Polyposis Syndrome Germline Predisposition by Performing Linkage Analysis Combined With Whole-Exome Sequencing
por: Toma, Claudio, et al.
Publicado: (2019)

S107: IDENTIFICATION AND CHARACTERIZATION OF GERMLINE NBN VARIANTS RELATED TO B-ALL PREDISPOSITION
por: Escherich, Carolin, et al.
Publicado: (2023)

Germline polymorphisms of circadian genes and gastric cancer predisposition
por: Rajendran, Senthilkumar, et al.
Publicado: (2020)

Germline MBD4 Mutations and Predisposition to Uveal Melanoma
por: Derrien, Anne-Céline, et al.
Publicado: (2020)

Examining the common and specific grey matter abnormalities in childhood maltreatment and peer victimisation
por: Lim, Lena, et al.
Publicado: (2022)

Whole-exome sequencing reveals a comprehensive germline mutation landscape and identifies twelve novel predisposition genes in Chinese prostate cancer patients
por: Liang, Yonghao, et al.
Publicado: (2022)

Revealing the molecular signatures of host-pathogen interactions
por: Khor, Chiea-Chuen, et al.
Publicado: (2011)

Clinical Outcome among Nasopharyngeal Cancer Patients in a Multi-Ethnic Society in Singapore
por: Mak, Han Wen, et al.
Publicado: (2015)

Germline Mutations in Cancer Predisposition Genes are Frequent in Sporadic Sarcomas
por: Chan, Sock Hoai, et al.
Publicado: (2017)

Heterozygous APC germline mutations impart predisposition to colorectal cancer
por: Preisler, Livia, et al.
Publicado: (2021)

Prevalence and clinical implications of germline predisposition gene mutations in patients with acute myeloid leukemia
por: Kim, Borahm, et al.
Publicado: (2020)

Germline Genetic NBN Variation and Predisposition to B-cell Acute Lymphoblastic Leukemia in Children
por: Escherich, Carolin, et al.
Publicado: (2023)

Characterizing the genetic differences between two distinct migrant groups from Indo-European and Dravidian speaking populations in India
por: Ali, Mohammad, et al.
Publicado: (2014)

Transcriptomic analyses of localized prostate cancers of East Asian and North American men reveal race‐specific luminal‐basal and microenvironmental differences
por: Chua, Melvin L. K., et al.
Publicado: (2023)

Identification of new Wilms tumour predisposition genes: an exome sequencing study
por: Mahamdallie, Shazia, et al.
Publicado: (2019)

Somatic inactivation of breast cancer predisposition genes in tumors associated with pathogenic germline variants
por: Lim, Belle W X, et al.
Publicado: (2022)

Familial Myelodysplastic/Acute Leukemia Syndromes—Myeloid Neoplasms with Germline Predisposition
por: Baptista, Renata Lyrio Rafael, et al.
Publicado: (2017)

Germline mutations in cancer-predisposition genes in patients with biliary tract cancer
por: Terashima, Takeshi, et al.
Publicado: (2019)

Biallelic germline nonsense variant of MLH3 underlies polyposis predisposition
por: Olkinuora, Alisa, et al.
Publicado: (2018)

Germline Variants in Phosphodiesterase Genes and Genetic Predisposition to Pediatric Adrenocortical Tumors
por: Pinto, Emilia Modolo, et al.
Publicado: (2020)

Lessons From Pediatric MDS: Approaches to Germline Predisposition to Hematologic Malignancies
por: Avagyan, Serine, et al.
Publicado: (2022)

Molecular reclassification reveals low prevalence of germline predisposition in children with ependymoma
por: Foss-Skiftesvik, Jon, et al.
Publicado: (2023)

Silver nanoparticles disrupt germline stem cell maintenance in the Drosophila testis
por: Ong, Cynthia, et al.
Publicado: (2016)

Identification of new breast cancer predisposition genes via whole exome sequencing
por: Southey, MC, et al.
Publicado: (2012)

Whole‐exome sequencing of ovarian cancer families uncovers putative predisposition genes
por: Zhu, Qianqian, et al.
Publicado: (2019)

Germline mutation in the RAD51B gene confers predisposition to breast cancer
por: Golmard, Lisa, et al.
Publicado: (2013)

Clinical Assessment and Diagnosis of Germline Predisposition to Hematopoietic Malignancies: The University of Chicago Experience
por: Desai, Ami V., et al.
Publicado: (2017)

Pathogenic Germline BRCA1/2 Mutations and Familial Predisposition to Gastric Cancer
por: Ichikawa, Hiroshi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ve1b2oc3ueqqpioi3tnjf2l9jr