Cargando…

A Journey through the Inter-Cellular Interactions in the Bone Marrow in Multiple Myeloma: Implications for the Next Generation of Treatments

SIMPLE SUMMARY: Here, we describe the main interactions of multiple myeloma cells in the bone marrow with non-hematological and hematological immune cells that impact the disease’s progression and treatment resistance. Non-hematological cells in the bone marrow can secrete molecules that accelerate...

Descripción completa

Detalles Bibliográficos
Autores principales: Hervás-Salcedo, Rosario, Martín-Antonio, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367481/
https://www.ncbi.nlm.nih.gov/pubmed/35954459
http://dx.doi.org/10.3390/cancers14153796
_version_ 1784765818500808704
author Hervás-Salcedo, Rosario
Martín-Antonio, Beatriz
author_facet Hervás-Salcedo, Rosario
Martín-Antonio, Beatriz
author_sort Hervás-Salcedo, Rosario
collection PubMed
description SIMPLE SUMMARY: Here, we describe the main interactions of multiple myeloma cells in the bone marrow with non-hematological and hematological immune cells that impact the disease’s progression and treatment resistance. Non-hematological cells in the bone marrow can secrete molecules that accelerate disease progression. On the other side, these interactions compromise immune cell activity, leading to immune evasion and disease progression. Deep knowledge of these interactions can lead to the design of improved treatments for multiple myeloma. ABSTRACT: Tumors are composed of a plethora of extracellular matrix, tumor and non-tumor cells that form a tumor microenvironment (TME) that nurtures the tumor cells and creates a favorable environment where tumor cells grow and proliferate. In multiple myeloma (MM), the TME is the bone marrow (BM). Non-tumor cells can belong either to the non-hematological compartment that secretes soluble mediators to create a favorable environment for MM cells to grow, or to the immune cell compartment that perform an anti-MM activity in healthy conditions. Indeed, marrow-infiltrating lymphocytes (MILs) are associated with a good prognosis in MM patients and have served as the basis for developing different immunotherapy strategies. However, MM cells and other cells in the BM can polarize their phenotype and activity, creating an immunosuppressive environment where immune cells do not perform their cytotoxic activity properly, promoting tumor progression. Understanding cell–cell interactions in the BM and their impact on MM proliferation and the performance of tumor surveillance will help in designing efficient anti-MM therapies. Here, we take a journey through the BM, describing the interactions of MM cells with cells of the non-hematological and hematological compartment to highlight their impact on MM progression and the development of novel MM treatments.
format Online
Article
Text
id pubmed-9367481
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93674812022-08-12 A Journey through the Inter-Cellular Interactions in the Bone Marrow in Multiple Myeloma: Implications for the Next Generation of Treatments Hervás-Salcedo, Rosario Martín-Antonio, Beatriz Cancers (Basel) Review SIMPLE SUMMARY: Here, we describe the main interactions of multiple myeloma cells in the bone marrow with non-hematological and hematological immune cells that impact the disease’s progression and treatment resistance. Non-hematological cells in the bone marrow can secrete molecules that accelerate disease progression. On the other side, these interactions compromise immune cell activity, leading to immune evasion and disease progression. Deep knowledge of these interactions can lead to the design of improved treatments for multiple myeloma. ABSTRACT: Tumors are composed of a plethora of extracellular matrix, tumor and non-tumor cells that form a tumor microenvironment (TME) that nurtures the tumor cells and creates a favorable environment where tumor cells grow and proliferate. In multiple myeloma (MM), the TME is the bone marrow (BM). Non-tumor cells can belong either to the non-hematological compartment that secretes soluble mediators to create a favorable environment for MM cells to grow, or to the immune cell compartment that perform an anti-MM activity in healthy conditions. Indeed, marrow-infiltrating lymphocytes (MILs) are associated with a good prognosis in MM patients and have served as the basis for developing different immunotherapy strategies. However, MM cells and other cells in the BM can polarize their phenotype and activity, creating an immunosuppressive environment where immune cells do not perform their cytotoxic activity properly, promoting tumor progression. Understanding cell–cell interactions in the BM and their impact on MM proliferation and the performance of tumor surveillance will help in designing efficient anti-MM therapies. Here, we take a journey through the BM, describing the interactions of MM cells with cells of the non-hematological and hematological compartment to highlight their impact on MM progression and the development of novel MM treatments. MDPI 2022-08-04 /pmc/articles/PMC9367481/ /pubmed/35954459 http://dx.doi.org/10.3390/cancers14153796 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hervás-Salcedo, Rosario
Martín-Antonio, Beatriz
A Journey through the Inter-Cellular Interactions in the Bone Marrow in Multiple Myeloma: Implications for the Next Generation of Treatments
title A Journey through the Inter-Cellular Interactions in the Bone Marrow in Multiple Myeloma: Implications for the Next Generation of Treatments
title_full A Journey through the Inter-Cellular Interactions in the Bone Marrow in Multiple Myeloma: Implications for the Next Generation of Treatments
title_fullStr A Journey through the Inter-Cellular Interactions in the Bone Marrow in Multiple Myeloma: Implications for the Next Generation of Treatments
title_full_unstemmed A Journey through the Inter-Cellular Interactions in the Bone Marrow in Multiple Myeloma: Implications for the Next Generation of Treatments
title_short A Journey through the Inter-Cellular Interactions in the Bone Marrow in Multiple Myeloma: Implications for the Next Generation of Treatments
title_sort journey through the inter-cellular interactions in the bone marrow in multiple myeloma: implications for the next generation of treatments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367481/
https://www.ncbi.nlm.nih.gov/pubmed/35954459
http://dx.doi.org/10.3390/cancers14153796
work_keys_str_mv AT hervassalcedorosario ajourneythroughtheintercellularinteractionsinthebonemarrowinmultiplemyelomaimplicationsforthenextgenerationoftreatments
AT martinantoniobeatriz ajourneythroughtheintercellularinteractionsinthebonemarrowinmultiplemyelomaimplicationsforthenextgenerationoftreatments
AT hervassalcedorosario journeythroughtheintercellularinteractionsinthebonemarrowinmultiplemyelomaimplicationsforthenextgenerationoftreatments
AT martinantoniobeatriz journeythroughtheintercellularinteractionsinthebonemarrowinmultiplemyelomaimplicationsforthenextgenerationoftreatments