TP53 Abnormalities Are Underlying the Poor Outcome Associated with Chromothripsis in Chronic Lymphocytic Leukemia Patients with Complex Karyotype

SIMPLE SUMMARY: Chromothripsis, a genomic event that generates massive chromosomal rearrangements, has been described in 1–3% of CLL patients and is associated with poor prognostic factors (e.g., TP53 abnormalities and genomic complexity). However, previous studies have not assessed its role in CLL...

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Autores principales: Ramos-Campoy, Silvia, Puiggros, Anna, Kamaso, Joanna, Beà, Sílvia, Bougeon, Sandrine, Larráyoz, María José, Costa, Dolors, Parker, Helen, Rigolin, Gian Matteo, Blanco, María Laura, Collado, Rosa, Ancín, Idoya, Salgado, Rocío, Moro-García, Marco A., Baumann, Tycho, Gimeno, Eva, Moreno, Carol, Salido, Marta, Calvo, Xavier, Calasanz, María José, Cuneo, Antonio, Nguyen-Khac, Florence, Oscier, David, Haferlach, Claudia, Strefford, Jonathan C., Schoumans, Jacqueline, Espinet, Blanca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367500/
https://www.ncbi.nlm.nih.gov/pubmed/35954380
http://dx.doi.org/10.3390/cancers14153715

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