Cargando…

Identification of Src as a Therapeutic Target in Oesophageal Adenocarcinoma through Functional Genomic and High-Throughput Drug Screening Approaches

SIMPLE SUMMARY: Oesophageal adenocarcinoma (OAC) is a leading cause of cancer mortality in the United Kingdom with a 5-year survival rate of approximately 15%. Major contributors to poor outcome are late diagnosis and chemotherapy resistance, and while targeted therapies have benefitted certain canc...

Descripción completa

Detalles Bibliográficos
Autores principales:	McCabe, Niamh H., Stevenson, Leanne, Scanlon, Enya, Douglas, Rosalie, Kennedy, Susanna, Keminer, Oliver, Windshügel, Björn, Zisterer, Daniela, Kennedy, Richard D., Blayney, Jaine K., Turkington, Richard C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367554/ https://www.ncbi.nlm.nih.gov/pubmed/35954391 http://dx.doi.org/10.3390/cancers14153726

Ejemplares similares

Glucose transporter 1 expression as a marker of prognosis in oesophageal adenocarcinoma
por: Blayney, Jaine K., et al.
Publicado: (2018)

Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma
por: Turkington, Richard C, et al.
Publicado: (2019)

Transcriptomic biomarkers for predicting response to neoadjuvant treatment in oesophageal cancer
por: Lavery, Anita, et al.
Publicado: (2021)

A DNA-damage immune response assay combined with PET biomarkers predicts response to neo-adjuvant chemotherapy and survival in oesophageal adenocarcinoma
por: Foley, Kieran G., et al.
Publicado: (2021)

Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma
por: Buckley, Amy M., et al.
Publicado: (2018)

Prior knowledge transfer across transcriptional data sets and technologies using compositional statistics yields new mislabelled ovarian cell line
por: Blayney, Jaine K., et al.
Publicado: (2016)

Review of applications of high-throughput sequencing in personalized medicine: barriers and facilitators of future progress in research and clinical application
por: Lightbody, Gaye, et al.
Publicado: (2019)

Apoptosis and autophagy markers predict survival in neoadjuvant treated oesophageal adenocarcinoma patients
por: El Mashed, Shereen, et al.
Publicado: (2022)

Src and Memory: A Study of Filial Imprinting and Predispositions in the Domestic Chick
por: Meparishvili, Maia, et al.
Publicado: (2021)

BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers
por: Buckley, Niamh E., et al.
Publicado: (2013)

The role of PTEN as a cancer biomarker
por: McCabe, Nuala, et al.
Publicado: (2016)

Characterisation of an Isogenic Model of Cisplatin Resistance in Oesophageal Adenocarcinoma Cells
por: Buckley, Amy M., et al.
Publicado: (2019)

Vitamin D receptor as a marker of prognosis in oesophageal adenocarcinoma: a prospective cohort study
por: McCain, Stephen, et al.
Publicado: (2018)

DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy
por: Gilmore, Elaine, et al.
Publicado: (2019)

Activation of MAPK signalling results in resistance to saracatinib (AZD0530) in ovarian cancer
por: McGivern, Niamh, et al.
Publicado: (2017)

Oesophageal adenocarcinoma: In the era of extended lymphadenectomy, is the value of neoadjuvant therapy being attenuated?
por: Park, Jin-Soo, et al.
Publicado: (2021)

Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma
por: Melo, Ashanty M., et al.
Publicado: (2019)

A biosensor generated via high throughput screening quantifies cell edge Src dynamics
por: Gulyani, Akash, et al.
Publicado: (2011)

Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma
por: Donlon, Noel E, et al.
Publicado: (2022)

Gene Expression Meta-Analysis Identifies VDAC1 as a Predictor of Poor Outcome in Early Stage Non-Small Cell Lung Cancer
por: Grills, Claire, et al.
Publicado: (2011)

Predicting Response to Neoadjuvant Therapy in Oesophageal Adenocarcinoma
por: Jiang, William, et al.
Publicado: (2022)

Gastro-oesophageal reflux disease and eosinophilic oesophagitis: What is the relationship?
por: Wong, Stephanie, et al.
Publicado: (2018)

Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma
por: Mongan, Ann Marie, et al.
Publicado: (2019)

Oesophageal Adenocarcinomas: Where Do We Stand Today?
por: Karstens, Karl-Frederick, et al.
Publicado: (2020)

3-Vinylazetidin-2-Ones: Synthesis, Antiproliferative and Tubulin Destabilizing Activity in MCF-7 and MDA-MB-231 Breast Cancer Cells
por: Wang, Shu, et al.
Publicado: (2019)

Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4
por: Malebari, Azizah M., et al.
Publicado: (2021)

Defining Unavoidable Delays in Primary Percutaneous Coronary Intervention: Discordance Among Patients Excluded From National Cardiovascular Quality Registries
por: McCabe, James M., et al.
Publicado: (2014)

PD-1 blockade enhances chemotherapy toxicity in oesophageal adenocarcinoma
por: Davern, Maria, et al.
Publicado: (2022)

Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib
por: Buckley, Amy M., et al.
Publicado: (2020)

Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer
por: Humphries, Matthew P., et al.
Publicado: (2018)

Oral Presentations: Circumferential Resection Margins in Oesophageal Carcinoma: A New Approach
por: J, Ahmad, et al.
Publicado: (2013)

Altered Mitochondrial Function and Energy Metabolism Is Associated with a Radioresistant Phenotype in Oesophageal Adenocarcinoma
por: Lynam-Lennon, Niamh, et al.
Publicado: (2014)

A compound combination screening approach with potential to identify new treatment options for paediatric acute myeloid leukaemia
por: Lappin, Katrina M., et al.
Publicado: (2020)

Modulation of human corticospinal excitability by paired associative stimulation
por: Carson, Richard G., et al.
Publicado: (2013)

Prairie ghost : pronghorn and human interaction in early America /
por: McCabe, Richard E.
Publicado: (2004)

Tonsillar metastasis of oesophageal adenocarcinoma
por: Struijs, Bram, et al.
Publicado: (2007)

The Evolution of Neo-Adjuvant Therapy in the Treatment of Oesophageal and Gastro-Oesophageal Junction Adenocarcinomas
por: Dermanis, Alexander A., et al.
Publicado: (2023)

SRC1, central to the nuclear periphery
por: Robinson, Richard, et al.
Publicado: (2008)

Type of medication therapy for ADHD and stimulant misuse during adolescence: a cross-sectional multi-cohort national study
por: Schepis, Ty S., et al.
Publicado: (2023)

Combination Therapies Targeting Apoptosis in Paediatric AML: Understanding the Molecular Mechanisms of AML Treatments Using Phosphoproteomics
por: Ali, Ahlam A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ls9t9n06hdj2gss2qhugbopp62