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TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies

The TGF-β signaling pathway plays a crucial role in several key aspects of development and tissue homeostasis. TGF-β ligands and their mediators have been shown to be important regulators of ocular physiology and their dysregulation has been described in several eye pathologies. TGF-β signaling part...

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Autores principales: Hachana, Soumaya, Larrivée, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367584/
https://www.ncbi.nlm.nih.gov/pubmed/35954181
http://dx.doi.org/10.3390/cells11152336
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author Hachana, Soumaya
Larrivée, Bruno
author_facet Hachana, Soumaya
Larrivée, Bruno
author_sort Hachana, Soumaya
collection PubMed
description The TGF-β signaling pathway plays a crucial role in several key aspects of development and tissue homeostasis. TGF-β ligands and their mediators have been shown to be important regulators of ocular physiology and their dysregulation has been described in several eye pathologies. TGF-β signaling participates in regulating several key developmental processes in the eye, including angiogenesis and neurogenesis. Inadequate TGF-β signaling has been associated with defective angiogenesis, vascular barrier function, unfavorable inflammatory responses, and tissue fibrosis. In addition, experimental models of corneal neovascularization, diabetic retinopathy, proliferative vitreoretinopathy, glaucoma, or corneal injury suggest that aberrant TGF-β signaling may contribute to the pathological features of these conditions, showing the potential of modulating TGF-β signaling to treat eye diseases. This review highlights the key roles of TGF-β family members in ocular physiology and in eye diseases, and reviews approaches targeting the TGF-β signaling as potential treatment options.
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spelling pubmed-93675842022-08-12 TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies Hachana, Soumaya Larrivée, Bruno Cells Review The TGF-β signaling pathway plays a crucial role in several key aspects of development and tissue homeostasis. TGF-β ligands and their mediators have been shown to be important regulators of ocular physiology and their dysregulation has been described in several eye pathologies. TGF-β signaling participates in regulating several key developmental processes in the eye, including angiogenesis and neurogenesis. Inadequate TGF-β signaling has been associated with defective angiogenesis, vascular barrier function, unfavorable inflammatory responses, and tissue fibrosis. In addition, experimental models of corneal neovascularization, diabetic retinopathy, proliferative vitreoretinopathy, glaucoma, or corneal injury suggest that aberrant TGF-β signaling may contribute to the pathological features of these conditions, showing the potential of modulating TGF-β signaling to treat eye diseases. This review highlights the key roles of TGF-β family members in ocular physiology and in eye diseases, and reviews approaches targeting the TGF-β signaling as potential treatment options. MDPI 2022-07-29 /pmc/articles/PMC9367584/ /pubmed/35954181 http://dx.doi.org/10.3390/cells11152336 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hachana, Soumaya
Larrivée, Bruno
TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies
title TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies
title_full TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies
title_fullStr TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies
title_full_unstemmed TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies
title_short TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies
title_sort tgf-β superfamily signaling in the eye: implications for ocular pathologies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367584/
https://www.ncbi.nlm.nih.gov/pubmed/35954181
http://dx.doi.org/10.3390/cells11152336
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