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Zinc pyrithione is a potent inhibitor of PL(Pro) and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication

Zinc pyrithione (1a), together with its analogues 1b–h and ruthenium pyrithione complex 2a, were synthesised and evaluated for the stability in biologically relevant media and anti-SARS-CoV-2 activity. Zinc pyrithione revealed potent in vitro inhibition of cathepsin L (IC(50)=1.88 ± 0.49 µM) and PL(...

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Detalles Bibliográficos
Autores principales:	Kladnik, Jerneja, Dolinar, Ana, Kljun, Jakob, Perea, David, Grau-Expósito, Judith, Genescà, Meritxell, Novinec, Marko, Buzon, Maria J., Turel, Iztok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367663/ https://www.ncbi.nlm.nih.gov/pubmed/35943189 http://dx.doi.org/10.1080/14756366.2022.2108417

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