Functional Versatility of the Human 2-Oxoadipate Dehydrogenase in the L-Lysine Degradation Pathway toward Its Non-Cognate Substrate 2-Oxopimelic Acid

The human 2-oxoadipate dehydrogenase complex (OADHc) in L-lysine catabolism is involved in the oxidative decarboxylation of 2-oxoadipate (OA) to glutaryl-CoA and NADH (+H(+)). Genetic findings have linked the DHTKD1 encoding 2-oxoadipate dehydrogenase (E1a), the first component of the OADHc, to path...

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Detalles Bibliográficos
Autores principales: Nemeria, Natalia S., Nagy, Balint, Sanchez, Roberto, Zhang, Xu, Leandro, João, Ambrus, Attila, Houten, Sander M., Jordan, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367764/
https://www.ncbi.nlm.nih.gov/pubmed/35897808
http://dx.doi.org/10.3390/ijms23158213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367764/
https://www.ncbi.nlm.nih.gov/pubmed/35897808
http://dx.doi.org/10.3390/ijms23158213

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